Journal of Photoscience
- 제9권2호
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- Pages.433-435
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- 2002
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- 1225-8555(pISSN)
Sphingosine-1-phosphate Promotes the Survival of Mel-Ab Cells via ERK and Akt activation
- Kim, Dong-Seok (Department of Dermatology, Seoul National University) ;
- Hwang, Eui-Soo (Department of Dermatology, Seoul National University) ;
- Kim, Sook-Young (Department of Dermatology, Seoul National University) ;
- Lee, Jai-Eun (Department of Dermatology, Seoul National University) ;
- Park, Kyoung-Chan (Department of Dermatology, Seoul National University)
- 발행 : 2002.08.01
초록
In the present study, we investigated the actions of sphingosine-I-phosphate (SPP) in Mel-Ab melanocytes. We observed the cytoprotective effect of SPP on UVB-induced cell death. Following exposure of cells to UVB, a significant protective effect was seen in cultures pretreated with SPP. Since SPP is well known as a mitogenic agent, it is possible that the mitogenic effect of SPP may contribute to cell survival. Surprisingly, we found that SPP inhibited DNA-synthesis significantly. We were next interested in the regulation of the extracellular signal-regulated protein kinase (ERK) and Akt pathways by SPP. We clearly observed that SPP potently stimulated the phosphorylation of both ERK and Akt against UVB-induced cell death. Based on these results, we conclude that SPP may show its cytoprotective effect through ERK and Akt activation.