Journal of Photoscience
- Volume 9 Issue 2
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- Pages.190-193
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- 2002
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- 1225-8555(pISSN)
Inhibition of Langerhans cell function by UVB radiation
- Okamoto, Hiroyuki (Department of Dermatology, Kansai Medical University) ;
- Mizuno, Kana (Department of Dermatology, Kansai Medical University) ;
- Horio, Takeshi (Department of Dermatology, Kansai Medical University)
- Published : 2002.08.01
Abstract
The functional disruption of Langerhans cells (LC) by UVB radiation is involved in antigen-specific immunosuppression of contact hypersensitivity. We tested whether UVB radiation inhibits the endocytotic activity of LC, which leads to impaired subsequent migration and maturation. Human monocyte-derived LC that took up lucifer yellow (L Y) or FITC-dextran (Fd) exclusively migrated in response to 6Ckine and matured. Exposing LC to 10-40 mJ/cm