Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Novel Benzoylurea Derivatives as Potential Antitumor Agents; Synthesis, Activities and Structure-Activity Relationships

  • Hwang, Ki-Jun (Department of Chemistry and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University) ;
  • Park, Kyung-Ho (Dupont CR＆D, Experimental Station, Wilmington) ;
  • Lee, Chong-Ock (Screening ＆ Toxicology Research Center, Korea Research Institute of Chemical Technology) ;
  • Kim, Beom-Tae (Department of Chemistry and Research Center of Bioactive Materials, College of Natural Science, Chonbuk National University)
  • Published : 2002.12.01
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Abstract

A series of pyrazoloxyphenyl benzoyl urea derivatives was designed and synthesized for cytotoxic evaluation as potential antitumor agents. The synthetic compounds were evaluated for in vitro cytotoxicity against five human tumor cell lines, including A-549, SKOV-3, SK-MEL-2, XF-498 and HCT-15. Among others, compound 11 exhibited 50∼100 times greater antitumor activities than the commercial product, Cisplatin.

Keywords

References

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