Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Antiangiogenic Activity of Bupleurum longiradiatum on human umbilical venous endothelial cells

  • You, Young-Jae (College of Pharmacy, Chungnam National University) ;
  • Lee, Im-Seon (College of Pharmacy, Chungnam National University) ;
  • Kim, Yong (College of Pharmacy, Chungnam National University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Ahn, Byung-Zun (College of Pharmacy, Chungnam National University)
  • Published : 2002.10.01
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Abstract

The ethyl acetate fraction of Bupleurum longiradiatum was found to have an inhibitory effect on the tube-like formation of human umbilical venous endothelial (HUVE) cells. The active compounds, isolated from the fraction, were identified as acetylbupleurotoxin (P1) and bupleurotoxin (P2). The compounds P1 and P2 completely inhibited the tube-like formation of HUVE cells at 30 ${\mu}g$/ml, below the cytotoxic concentration. But, they did not exhibit antitumor activity on BDF1 mice bearing Lewis lung carcinoma cells despite their antiangiogenic activity.

Keywords

References

  1. Bae, K. H., You, Y J., Park, J. Y, An, R. B., Kim,Y H., Kang, J. S. and Ahn, B. Z., Screening of angiogenesis inhibitors from Korean plants (I). Kor. J. Pharmacogn., 31(3), 320-324 (2000)
  2. Nam, N. H., Lee, C. W., Hong, D. H., Kim, H. M., Bae, K., and Ahn, B. Z., Antiinvasive, antiangiogenic and antitumor activity of Ephedra sinica extract. Phytother. Res., 16, 1-7 (2002)
  3. Nam, N. H., Kim, H. M., Bae, K., and Ahn, B. Z., Inhibitory effects on Vietnamese medicinal plats on tube-like formation of human umbilical veinous cells. Phytother. Res., in press
  4. Kim, Y, Kim, S. B., You, Y J. and Ahn, B. Z., Deoxypodophyllotoxin; the cyttotoxic and antiangiogenic component from Pulsatilla koreana. Plant Med., 68, 271-274 (2002) https://doi.org/10.1055/s-2002-23140
  5. Kim, Y. H., Lee, S. S., Bae, K., Kim, H. S. and Lee, M. -G., Effects of herbal medicines on monoamine oxidase activity (Ⅱ). Yakhak Hoechi, 42(6), 634-638 (1998)
  6. You, Y J., Kim, Y, Nam, N. H. and Ahn, B. Z., Antiangiogeic activity of lupeol from Bombax ceiba on tube formation of human umbilical veneous endotherial cells. Phytother. Res., in press
  7. Zhao, J., Guo, Y, and Meng, X., The toxic principles of Bupleurum longiradiatum. Yaoxue Xuebao, 22(7), 507-511 (1987)
  8. Zhao, J., Guo, Y, Meng, X., Poisonous constituents of Bupleurum longiadiatum Turcz. Shenyang Yaoxueyuan Xuebao, 2(4),301 (1985)