약학회지 (YAKHAK HOEJI)

  • 제46권6호
  • /
  • Pages.369-374
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  • 2002
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  • 0377-9556(pISSN)
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  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

3-멀？토-4H-피롤로피리딘의 합성

Synthesis of 3-mercapto-4H-pyrrolopyridine

  • 마은숙 (대구가톨릭대학교 약학대학)
  • 발행 : 2002.12.01
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초록

Dilithiation of 4-(pivaloylamino)pyridine (5) followed by reaction with tetraisopropylthiuram disulfide(TITD) gave rise to 3-(diisopropyldithiocarbamato)-4-(pivaloylamino)pyridine (6). 3-Mercapto-4H-pyrrolopyridine(2) was synthesized from compound 6 by two methods. The first method was that compound 6 was treated with 5M-HCl to form 2-t-butylthiazolo[5,4-c]pyridine (7) and hydrolysed in refluxing 10％ NaOH and solid NaOH to prepare bis(4-amino-3-pyridyl)disulfide (8). And compound 8 was reacted with 2,5-dimethoxytetrahydrofuran and NaBH$_4$ to afford compound 2. The second method was that compound 6 was hydrolysed with 10％ NaOH and followed to react with 2,5-dimethoxytetrahydrofuran to form compound 11. And then compound 11 was treated with 20％ ethanolic KOH solution to synthesize compound 2.

키워드

참고문헌

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