3-멀?토-4H-피롤로피리딘의 합성

Synthesis of 3-mercapto-4H-pyrrolopyridine

  • 마은숙 (대구가톨릭대학교 약학대학)
  • 발행 : 2002.12.01

초록

Dilithiation of 4-(pivaloylamino)pyridine (5) followed by reaction with tetraisopropylthiuram disulfide(TITD) gave rise to 3-(diisopropyldithiocarbamato)-4-(pivaloylamino)pyridine (6). 3-Mercapto-4H-pyrrolopyridine(2) was synthesized from compound 6 by two methods. The first method was that compound 6 was treated with 5M-HCl to form 2-t-butylthiazolo[5,4-c]pyridine (7) and hydrolysed in refluxing 10% NaOH and solid NaOH to prepare bis(4-amino-3-pyridyl)disulfide (8). And compound 8 was reacted with 2,5-dimethoxytetrahydrofuran and NaBH$_4$ to afford compound 2. The second method was that compound 6 was hydrolysed with 10% NaOH and followed to react with 2,5-dimethoxytetrahydrofuran to form compound 11. And then compound 11 was treated with 20% ethanolic KOH solution to synthesize compound 2.

키워드

참고문헌

  1. Krapcho, J., Spitzmiller, E. R., and Turk, C. F. : Substituted 2,3dihydro-1,5-benzothiazepin-4(5H)-ones and 3,4-dihydro-2phenyl-(2H)-1,6-benzothiazo cin-5(6H)-ones. J. Med. Chem. 6, 544 (1963) https://doi.org/10.1021/jm00341a017
  2. Kugita, H., Inoue, H., Iakesaki, M., Konda, M., and Takeo, S. : Synthesis of 1,5-benzothiazepine. Chem. Pharm. Bull. 19, 595 (1971)
  3. Nagao, T., Sato, M., Nagajima, H., and Kiyomoto, A. : Studies on an new 1,5-benzothiazepine derivatives(CRD-401) IV. Coronary vasodilating effect and structure-activity relationship. Chem. Pharm. Bull. 21, 92 (1973)
  4. Inoue, H., Gaino, M., Hashiyama, T., Otsuka, H., Takehshi, K., Date, T., Aoe, K., Takeda, M., Murata, S., Narita, M., and Nagao, T. : Synthesis of halogenated 1,5-benzothiazepine derivatives and their vasodilating and hypotensive activities. J. Med. Chem. 34, 675 (1991) https://doi.org/10.1021/jm00106a032
  5. Ohno, S., Izumi, K., Mizukoshi, K., Kato, K., and Hori, M. : Synthesis of a new potent anti-ulcer and gastric secretory inlubiting agent, (-)-cis-2,3-dihydro-3-(4-methylpiperazinyhnethyl)2-phenyl-1,5-benzothiazepin-4(5H)-one hydrochloride(BTM1086), and related compounds. Chem. Pharm. Bull. 31, 1780 (1983)
  6. Garofalo, A., Nacci, V., Carelli, F., and Campiani, G. : Polycondensed heterocycles. V. Synthesis of 5H,11H-pyrrolo[2,1-c][1,4]benzothiazepine. Heterocycles 31, 1291 (1990).
  7. Garofalo, A., Campiani, G., Nacci, V., and Fiorini I. : Polycondensed heterocycles. VIII. Synthesis of 11-aryl-5H,11H-pyrrolo[2,1-c][1,4]benzothiaze pines by Pummerer rearrangement-cyclization reaction. Heterocycles 34, 51 (1992).
  8. Silvestri, R., Pagnozzi, E., Stefanich, G., and Artico, M. : Heterocycles with a benzothiazepine moiety. 4. Synthesis of novel tetracyclic rings by intramolecular cyclization of 10-bromoacetyl-10,11-dihydro-11-ethoxycarbonyl pyrrolo[1,2-b][1,2,5]benzothiadiazepine-5,5-dioxide and its derivatives. Synth. Commun. 24(19), 2685 (1994).
  9. Artico, M., Stefanich, G., Silvestri, R., Massa, S., Pagnozzi, E., Loi, A.G., Musu, D., Doa, M., Scano, P., and Colla, P. : Pyrrolobenzothiazepines : A new class of non-nucleoside HIV-1 reverse transcriptase inhibitors. Med. Chem. Res. 4, 283 (1994)
  10. Couture, A., Deniau, E., Grandclaudon, P., and Simion, C. : A facile synthesis of substituted 1,4-benzothiazepin-5(4H)-ones and pyrido[3,2-f][1,4]thiazepin-5(4H)-ones : Crystal and molecular structure of 2-ethylthio-4-methyl-5(4H)-oxopyrido[3,2-f][1,4]thiazepine-3-carbonitrile. Eur. J. Org. Chem. 1237 (1998).
  11. Couture. A., Huguerre, E., and Grandclaudon, P. : A new synthetic mute to the previously unattainable 2-arylpyrido[2,3-b][1,5]thiazepin-4(5H)-ones. J. Org. Chem. 55, 4337 (1990). https://doi.org/10.1021/jo00301a025
  12. Couture. A., Deniau, E., Grandclaudon, P., and Simion, C. : A short synthesis of 2,3-di(hetero)arylpyrido[3,2-f][1,4] thiazepines. Synthesis 986 (1996).
  13. Cale, A. D., Gem, T. W., Walker, K. R., Lo, Y. S., Welstead, W. J., Jaques, L.W., Johnson, A. E., Leonard, C. A., Nolan, J. C., and Johason, D. N. : Benzo- and pyrido-1,4-oxazepin-5-ones and thiones: Synthesis and structure-activity relationships of new series of H1 antihistamines. J. Mal. Chem. 32, 2178 (1989)
  14. Fuhrer, W., and Gschwend, W. : Ortho functionalization of aromatic amines: ortho lithiation of N-pivaloylaniline. J. Org. Chem. 44(17), 1133 (1979)
  15. Jen, K.-Y., and Cava, M. P. : A new synthesis of aromatic thiols. Tetrahedron Lett. 23(19), 2001 (1982)
  16. Wang, H.-M., Lin, M.-C., and Chen, L.-C. : Synthesis of 4H-pyrrolo[2,1-c][1,4]benzothiazines and 3-(methylthio) oxindoles. J. Chin. Chem. Soc. 41, 217 (1994).