YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Anti-lipid Peroxidative Effect of Extracts and its Fractions Polygonatum odoratum

둥굴레 추출물 및 분획의 과산화지질 생성 저해효과

  • 김주향 (숙명여자대학교 약학대학) ;
  • 양기숙 (숙명여자대학교 약학대학)
  • Published : 2002.08.01
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Abstract

The rhizoma of Polygonatum odoratum (Liliaceae) promotes the production of body fluid and relives dryness symptoms and has hypoglycemic effect. In order to evaluate the prevention of lipid peroxidative efficacy of P. odoratum, its extracts (Et$_2$O and MeOH ex.) and its fractions ($H_2O$, 20％ MeOH, 40％ MeOH, 60％ MeOH and 100％ MeOH fr.) were measured by TBARS assay on rat liver S9 and human erythrocyte ghost membrane. The order of anti-lipid peroxidative effect was as follows: Et$_2$O ex. ＞40％ MeOH fr. ＞60％ MeOH fr.＞100％ MeOH fr. Based on these results, we conclude that membrane lipid peroxidation is inhibited in vitro by addition of P. odoratum ether extract and its gradient MeOH fractions excepts $H_2O$ fr., and which have significant hepatoprotective activity in $CCl_4$-treated rats.

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References

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