YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Simultaneous HPLC Determination of Preservatives in Cosmetics

화장품중 살균ㆍ보존제의 동시분리 및 정량

  • 양성준 (식품의약품안전청 의약품평가부 의약외품과) ;
  • 김영옥 (식품의약품안전청 의약품평가부 의약외품과) ;
  • 손경훈 (식품의약품안전청 의약품평가부 의약외품과) ;
  • 이정표 (식품의약품안전청 의약품평가부 의약외품과) ;
  • 정래석 (식품의약품안전청 의약품평가부 의약외품과) ;
  • 양원준 (식품의약품안전청 의약품평가부 의약외품과) ;
  • 백옥진 (식품의약품안전청 의약품평가부 의약외품과) ;
  • 이현경 (상명대학교 공업화학과) ;
  • 최상숙 (식품의약품안전청 의약품평가부 의약외품과)
  • Published : 2002.08.01
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Abstract

A high-performance liquid chromatographic method for the simultaneous quantitative analysis of methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP) and imidazolidinyl urea(IU) or diazolidinyl urea(DU) in cosmetics was studied by using a cyano-propyl column and 0.05M hexanesulfonic acid at 228 nm. Calibration curves were found to be linear in the 60-1000 $\mu\textrm{g}$/mL range (parabens), 100-1,250 $\mu\textrm{g}$/mL range (IU) and the 120-2000 $\mu\textrm{g}$/mL range (DU). Linear regression analysis of the data demonstrates the efficacy of the method in terms of precision and accuracy. An extraction method is developed and validated in order to apply this chromatographic method to a commercial cosmetic cream. The precision of this method, calculated as the relative standard deviation (RSD) of the recoveries (0.46-2.71％) was excellent for all compounds.

Keywords

References

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