Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
권호 표지

General Pharmacology of AS6

AS6의 일반약리작용시험

  • 김현진 (한국화학연구원 부설 안전성평가연구소) ;
  • 최규갑 (한국화학연구원 부설 안전성평가연구소) ;
  • 도선희 (한국화학연구원 부설 안전성평가연구소) ;
  • 김은주 (한국화학연구원 부설 안전성평가연구소) ;
  • 차경회 (동국제약 주식회사)
  • Published : 2002.12.01
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Abstract

In this study the general pharmacological profiles of AS6 on the central nervous system, cardiovascular and the other organs were investigated. The dosages given were 0, 250, 500 and 1000 mg/kg and drugs were orally administered. The animals used for this study were mice, rats and guinea pigs. Significant increases (p<0.01) in the charcoal transport capacity were observed at the high dose of 1000 mg/kg and significant increases in retardation of pain threshold were observed in the test using acetic acid in all dosed animals. However, AS6 showed no noticeable effects on general behavior, motor coordination, spontaneous locomotor activity, hexobarbital-induced sleep time, body temperature, analgesic activity in the test using hot plate method and anticonvulsant activity. Furthermore no noticeable effects were observed in cardiovascular functions in the isolated rat heart, contraction and relaxation of the smooth muscle in the isolated guinea ileum, gastric secretion and renal function.

Keywords

References

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