Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
권호 표지

The Effect of Achyranthis Radix Extract on Hard Tissure Regeneration

우슬 추출물의 경조직 재생촉진효과

  • Published : 2002.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study was performed to investigate therapeutic effects of Achyranthis Radix extract and chitosan on the growth and differentiation of rat calvarial cells. it was found that treatment of methanol extract of Achyranthis Radix for 2 days caused 2.4-fold increase in the growth of rat calvarial cells. However, chitosan treatment caused only 1.9-fold increase in the cell growth. Treatment of methanol extract of Achyranthis Radix for 14 days caused 2-fold increase in the growth of rat calvarial cells. Alkaline phosphatase activity, one of the markers for bone cell differentiation, was increased approximately by 1.7-fold and 2.9-fold by the treatment of methanol extract of Achyranthis Radix for 2 days and 14 days, respectively. These results suggest that Achyranthis Radix extract could be beneficial for bone regeneration.

Keywords

References

  1. Ackemiann, R. and Predine, M. (1968). Hospital testing the unsaponifiable part of Maize oil. L 'Information Dentaire, 8, 751-758
  2. Arvey, J.K. (1988). Oral development and histology. B.C. Decker Inc. Toronto
  3. Bellot, J. and Dargcnt, P. (1979). Tretment of chronic periodontitis. A clinical and histological study of the activity of a standard extract of the unsaponifiable fraction of Zea Mays L., La Vie Medicale, 60, 1335-1363
  4. Chaput, A. (1964). Insadol and Parodontolysis. L 'Information Dentaire, 23, 2148-2153
  5. Chung, C-R, Pai-k, J.-B., and Bae, K.-H. (1995). Pharmacological effects of methanolic gingival fibroblast. Planta Medica, 61, 150-153 https://doi.org/10.1055/s-2006-958036
  6. Colombel, J. and Parente, C. (1974). Trial of the unsaponifiablefraction of Zw Mays L. on dryness of the mouth induced psychotropic drug. Progress Odonto-Stomatologiques, 12, 31-33
  7. Egelberg, J. (1987). Regeneration and repair of pehodontal defects. J. Periodont Res., 22, 233-242 https://doi.org/10.1111/j.1600-0765.1987.tb01577.x
  8. Fourel, J., Siau, T. and Barka, A. (1967). Clinical trials of the unsaponifiable part of Maize seed oil in periodontic. L'lnformation Dentaire, 8, 749-753
  9. Genco, R.J., Goldman, H.M. and Cohen, D.W. (1990). Contemporary periodontics, C.V. Mosby, St. Louis, 47-54
  10. Kerebel, B., Cleargeau-Guerithault, S. and Brion, M. (1975). A scanning electron microscopic study of experimental periodontal disease, Its induction and inhibition. J. Periodontal., 46. 27-32 https://doi.org/10.1902/jop.1975.46.1.27
  11. Kerebel, B. and Dacilsi, G. (1977). A semi-quantitative study of experimental pehodontal disease and bone repair in the golden hamster. Jour. Biol. Buccale, 5, 77-84
  12. Li, X.P. (1991) Experimental study on anti-senility of the 4 famous Chinese herbs produced in Huaiqing area. Zhong Xi Yi Jie He Za Zhi, 11(8), 486-487
  13. Motomura, Y, Miyata, T., Arald, H., Shin, K., Sugimoto, H., Hanazawa, S., Kitano, S., lkeda, K. (1994). A study of the infliencc of crude drugs on periodontal pockets (Part I). J. Japan.. Soc. Periodontol, 36(2), 474-479 https://doi.org/10.2329/perio.36.474
  14. Motoroura, Y., Miyata, T., Araki, H., Shin, K., Sugiinoto, H., Kobayashi, Y., Ikeda, K. (1995). A study of the inflicnce of crude drugs on periodontal pockets (Part II)-Inhibitory effect of Lonicerae Flos on MCP-l and IL-6 gene expression by human gingival fibroblasts treaed with IL-l. J. Japan.. Soc. Periodontol., 37(1), 134-140 https://doi.org/10.2329/perio.37.134
  15. Son, S. (1982). Influence of standard extract of the unsaponiliable fraction of Zea Mays L. on periodontal disease. Ouentessence Int'l., No. 8, 1-7
  16. Sugawara, Y, Suzuki, K., Koshikawa, M., Ando, M., lida, J. (2002) Necessity of enzymatic activity of alkaline pbosphatase for mineralization of osteoblastic cells. Jpn. J. Pharmacol., 88, 262-269 https://doi.org/10.1254/jjp.88.262
  17. Taguchi K., Hagiwara Y., Kajiyama K. and Suzuki Y. (1993). Pharmacological studies of Houttuyniae herba: The antiinflammatiiy effect of Quercitrin. Yakugaku Zassht, 113(4), 327-333 https://doi.org/10.1248/yakushi1947.113.4_327
  18. Tecucianu J. (1975). Double blind clinical trial of titrated extract of the unsaponifiable fraction of Zea Mays L. on gingival inflammation, Inf. Den., 51, 21-32
  19. Ten Catc, A.R: Oral histology (1989). Development, structure, and function. 3rded. The C.V. Mosby Co., St. Louis, Baltimore, Toronto 90-105
  20. Thiers, Jouaimeteau and Zwingelstein (1958). The Maize germ oil insaponifiable its therapeutical indications, Press Medicale, July 26, , 66, 56, 1293-1294
  21. Togari, A., Arakawa, S., Arai, M., Matsumoto, S. (1993) Inhibition of in vitro mineralization m osteoblastic cells and in mouth tooth germ by phospbatidyl-specific phospholipase C. Biochem. Pharmacol, 46, 1668-1670
  22. Xie, E, Li, X., Sun, K., Chm, Y, Cao, H., Chen, N., Wang, W.. Liu, M., Liu, W., Mao, D. (2001) An experimetal study on drugs for improving blood circulation and removing blood stasis in treating mild chronic hepatic damage. J. Tradit. Chin. Med., 21(3), 225-231
  23. Yasukawa K., Takido M., Takeuchi M., Nakagawa S. (1989).Effect of chemical consistituents from plants on 12-0- tetradecanoyl-phomoyl-13-acelate-induced inflammation in mice. Chem. Pham. Bull., 37, 1071
  24. Yoshikawa, M., Suzuki, K., Kajii, T., Koshikawa, M., Imai, T., and Matsumoto, A. (1999) Quantitative analysis of alkaline phosphatase activity and mineralization of a clonal Osteob1ast-ike cell MC3T3-E1. J. Hard Tissue Biol.., 8, 37-42
  25. 류인철, 손성희, 정중평, 배기환 (1993). 생악 추출물이 세포성장 및 Cytokine 생산에 미치는 영항. 대한 치주과학회지 23(1), 37-47
  26. 민원기, 이만섭 (1988). Ascorbic acid화 Zea Mctys L.의 불검화 정량푸출물이 치주염 치유에 미치는 영향에 관한 실험적 연구, 대한 치주과학회지, 18(2), 6-23
  27. 양창호, 류인철, 최상묵. 정종평 (1995). 치은섬유이세포와 치주인대세포의 형태와 화학주성에 미치는 대조추출물의 효과에 관한 연구. 대한 치주과학회지 25(2), 279-289
  28. 육창수 등, 현대 생약학, 서울, 학창사, 24-128. 1993장범석, 손성희, 정종평, 배기환 (1993). Magnolol과 Hinokiol이 항균, 교원질 분해효소, 세포독성 Cytokine 생산에 미치는 영향. 대치주지 23(1), 145-158
  29. 점세영, 박준봉, 라건구, 권영혁, 김성진 (2001) 홍화자 추출물과 키토산 병용치리에 의한 경조직 재생촉진 효과. 응용약물학회지 9, 244-248
  30. 최상묵, 한수부, 황광세 (1989) Zea Mays L.의 불검화 정량 추출물이 외과적 치주 치교후의 치유에 미치는 효과에 관한 임상적 연구, 대한 치주과학회지, 19(1), 63-70
  31. 한경윤, 박준봉, 정진형. 정종평 (1994) 한국인의 치주조직 상태에 관한 역학조사. 대한치주과학회지 24(3), 458-471