Hepatoprotective and Anti-diabetic Effects of Pelvetia siliquosa, a Marine Algae, in Rats

  • Lee, Yeon-Sil (Natural Products Research Institute, Seoul National University) ;
  • Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University) ;
  • Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University) ;
  • Choi, Yong-Jo (Natural Products Research Institute, Seoul National University) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University)
  • Published : 2002.09.01


The effects of various fractions from the whole plant of Pelvetia siliquosa Tseng et Chang (Fucaceae) on the $CCl_4$-induced hepatotoxicity as well as on streptozotocin (STZ)-induced diabetes in rats were investigated. The ether fraction exhibited a potent rat lens aldose reductase (RLAR) inhibition in vitro and showed a significant inhibition of not only serum glucose concentrations but also sorbitol accumulations in the lens, red blood cells and sciatic nerves in the STZ-induced diabetic rats. When administered orally in Sprague-Dawley rats, $H_{2}O$ fraction was found to cause a significant inhibition of the rise in the serum transaminase activities in $CCl_4$-intoxicated rats. These results suggested that this plant might possess constituents with hepatoprotective, anti-diabetic effects and those effects on diabetic complications.



  1. Aybar, M. J., Sanchez Riera, A. N., Grau, A., Sanchez, S. S. (2001). Hypoglycemic effect of the water extract of Smallan- tus sonchifolius (yacon) leaves in normal and diabetic rats. J. Ethnopharmacol., 74, 125-132 https://doi.org/10.1016/S0378-8741(00)00351-2
  2. Clements, R. S., Jr. Morrison, A. D. Winegard, A. I. (1969). Poly pathway in aorta: rcgulation by hormones. Science, 166, 1007- 1008 https://doi.org/10.1126/science.166.3908.1007
  3. Drabkin, D. S. and Ausin, J. H. (1932). Spectrophotometirc con- stants for common hemoglobin derivatives in human, dog, and rabbit blood. J. Biol. Chem., 98, 719
  4. Hayman, S. and Kinoshila, J. H. (1965). Isolation and properties of lens aldose reductase. J. Biol. Chem., 240, 877-882
  5. Kinoshita, J. H., Fukushi, S., Kador, P. and Merola, L. O. (1979). Aldose reductase in diabetic complications of the eye. Metabo- lism, 28, 462-469 https://doi.org/10.1016/0026-0495(79)90057-X
  6. Kinoshita, J. H. (1974). Mechanism initiating cataract formation. Invest. Ophthalmol., 13, 713-723
  7. Malone, J. I., Knox, G., Benford S., Tedesco T. A. (1980). Red cell sorbitol: an indicator of diabetic control. Diabetes, 29, 861-864 https://doi.org/10.2337/diabetes.29.11.861
  8. McCay, P. B., Lai, E. K., Poyer, J. L., DuBose, C. M., Janzen, E. G. (1984). Oxygen- and carbon-centered free radical forma- tion during carbon tetrachloride metabolism. Observa-tion of lipid radicals in vivo and in vitro. J. Biol. Chem., 259, 2135- 2143
  9. Oh Y. S., Lee I. K., Boo S. M. (1990). An annotated account of Korean economic seaweeds for food, medical and industrial uses. Kor. J. Phycol., 5, 57-71
  10. Raskin, P. and Rosentstock, J. (1987). Aldose reductase inhibi- tors and diabetic complications. Am. J. Med., 83, 298-306 https://doi.org/10.1016/0002-9343(87)90702-9
  11. Sato, S. and Kador, P. F. (1990). Inhibition of aldehyde reductase by aldose reductase inhibitors. Biochem. Phramacol., 40, 1033- 1042 https://doi.org/10.1016/0006-2952(90)90490-C
  12. Trinder, P. (1969). Determination of glucose using glucose oxi- dase with an alternative oxygen acceptor. Ann. Clin. Biochem., 6, 24-27 https://doi.org/10.1177/000456326900600108
  13. Yoon J. T. (1995). Developmental morphology on the regenera- tion of Pelvetia siliquosa Tseng and Chang, Phaeophyta in Korea. Chonbuk National University. Ph. D. Thesis. 100