Environmental Analysis Health and Toxicology

The Korean Society of Environmental Health and Toxicology (환경독성보건학회)
권호 표지

Association between Genetic Polymorphism of the Human Angiotensin I Converting Enzyme Gene ana Athletic Performance

한국인 운동선수군에서 안지오텐신 전환효소 유전자의 다형성과 심폐 지구력과의 관련성에 관한 연구

  • Kang, Byung-Yong (Research Institute for Life Science, Sahmyook University) ;
  • Oh, Sang-Duk (College of Physical Education, Hanyang University) ;
  • Bae, Joon-Seol (Seoulin Bioscience Institute, Seoulin Bioscience, Co. Ltd.) ;
  • Kim, Ki-Tae (Seoulin Bioscience Institute, Seoulin Bioscience, Co. Ltd.) ;
  • Kim, Jae-Hyoun (Dept. of Health Science, College of Natural Science, Dongduk Women’s University) ;
  • Lee, Kang-Oh (Dept. of Life Science, Sahmyook University)
  • Published : 2002.12.01
Download PDF
⟨ Previous Next ⟩

Abstract

심폐 지구력은 유전인자에 의해 부분적으로 결정되며, 현재까지 이루어진 연구 결과에 의하면 안지오텐신 전환효소 유전자에 존재하는 다형성과 이 형질 사이에 유의한 관련성이 보고되고 있다. 그러나, 이러한 연구는 주로 서양인을 대상으로 수행되었기 때문에 유전적 배경이 다른 아시아 집단에 대해서는 아직까지 이렇다 할 연구 성과가 없는 실정이다. 이에, 본 연구에서는 아시아 집단중에서도 민족적으로 순수한 한국인 집단을 대상으로 안지오텐신 전환효소 유전자에 존재하는 다향성이 한국인 집단에서도 심폐 지구력과 유의한 관련성이 있는 지를 조사하였다. 그러나, 한국인 운동선수군을 대상으로 한 연구에서는 안지오텐신 전환효소 유전자의 다향성이 심폐 지구력을 비롯한 신체 계측치 및 생화학적인 측정치 들과 어떠한 관련성도 나타내지 않았다(P＜0.05). 그러나, 본 연구 대상으로 다양한 종목에서 선발된 운동선수들을 표본으로 하였기 때문에, 단일 종목의 운동 선수군을 대상으로 한 추시가 요구된다.

Keywords

References

  1. Alvarez R, Terrados N, Ortolano R, Iglesias-Cubero G, Reguero JR, Batalla A, Cortina A, Fernandez-Garcia B, Rodriguez C, Braga S, Alvarez V and Coto E, Genetic variation in the renin-angiotensin system and athletic performance, Eur. J. Appl. Physiol. 2000; 82: 117-120 https://doi.org/10.1007/s004210050660
  2. Barley J, Blackwood A, Carter ND, Crews DE, Cruickshank JK, Jeffery S, Ogunlesi AO and Sagnella GA, Angiotensin converting enzyme insertion/deletion polymorphism: association with ethnic origin, J. Hypertens. 1994; 12: 955-957
  3. Bloem LJ, Manatunga AK and Pratt JH, Racial difference in the relationship of an angiotensin I-converting enzyme gene polymorphism to serum angiotensin I-converting enzyme activity, Hypertension 1996; 27: 62-66 https://doi.org/10.1161/01.HYP.27.1.62
  4. Botstein D, White RL, Skolnick M and Davis RW, Construction of a genetic linkage map in man using restriction fragment length polymorphisms, Am. J. Hum. Genet. 1980; 32: 314-331
  5. Cambien F, The angiotensin-converting enzyme (ACE) genetic polymorphism: its relationship with plasma ACE level and myocardial infarction, Clin. Genet. 1994; 46: 94-101 https://doi.org/10.1111/j.1399-0004.1994.tb04210.x
  6. Cambien F, Alhenc-Gelas F, Herbeth B, Andre JL, Rakotovao R, Gonzales MF, Allegrini J and Bloch C, Familial resemblance of plasma angiotensin-converting enzyme level: the Nancy study, Am. J. Hum. Genet. 1988; 43: 774-780
  7. Cambien F, Poirier O, Recerf L, Evans A, Cambou JP, Arveiler D, Lue G, Bard JM, Bara L, Ricard S, Tiret L, Amouyel P, Alhenc-Gelas F and Soubrier F, Deletion polymorphism at the angiotensin-converting enzyme gene is a potent risk factor for myocardial infarction, Nature 1992; 359: 641-644 https://doi.org/10.1038/359641a0
  8. Dionne FT, Turcotte L, Thibault MC, Boulay MR, Skinner JS and Bouchard C, Mitochondrial DNA sequence polymorphism, VO$_{2max}$, and response to endurance training, Med. Sci. Sports Exerc. 1993; 25: 766-774 https://doi.org/10.1249/00005768-199307000-00002
  9. Fatini C, Guazzelli R, Manetti P, Battaglini B, Gensini F, Vono R, Toncelli L, Zilli P, Capalbo A, Abbate R, Gensini GF and Galanti G, RAS genes influence exercise-induced left ventricular hypertrophy: an elite athletes study, Med. Sci. Sports Exerc. 2000; 32: 1868-1872 https://doi.org/10.1097/00005768-200011000-00008
  10. Friedwld WT, Levy RI and Friedrickson DS, Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge, Clin. Chem. 1972; 18: 499-502
  11. Gagnon J, Ho-Kim MA, Chagnon YC, Perusse L, Dionne T, Leon AS, Rao DC, Skinner JS, Wilmore JH and Bouchard C, Absence of linkage between $VO_{2max}$ and its response to training with markers spanning chromosome 22. Med. Sci. Sports Exerc. 1997; 29: 1448-1453 https://doi.org/10.1097/00005768-199711000-00010
  12. Gayagay G, Yu B, Hambly B, Boston T, Hahn A, Celermajer DS and Trent RJ, Elite endurance athletes and the ACE I allele-the role of genes in athletic performance, Hum. Genet. 1988; 103: 48-50 https://doi.org/10.1007/s004390050781
  13. Hong SH, Kang BY, Park WH, Kim JQ and Lee CC, Genetic variation of the angiotensin-converting enzyme gene: Increased frequency of the insertion allele in Koreans, Clin. Genet. 1997; 51: 35-38 https://doi.org/10.1111/j.1399-0004.1997.tb02411.x
  14. Inagami T, Guo DF and Kitami Y, Molecular biology of angiotensin II receptors: an overview, J. Hypertens. 1994; 12(suppl 10) S83-S94
  15. Johanning GL, Johnston KE, Tamura T and Goldenberg RL, Ethnic differences in angiotensin converting enzyme gene polymorphism, J. Hypertens. 1995; 13: 710-711
  16. Kaski JC, Are polymorphisms in the ACE gene a potent genetic risk factor for restenosis? Br. Heart J. 1994; 72: 101 https://doi.org/10.1136/hrt.72.2.101
  17. Murakami H, Soma R, Hayashi JJ, Katsuta S, Matsuda M, Ajisaka R, Okada M and Kuno S, Relationship between mitochondrial DNA polymorphism and the individual differences in aerobic performance, Jpn. J. Physiol. 2001; 51: 563-568 https://doi.org/10.2170/jjphysiol.51.563
  18. Myerson S, Hemingway H, Budget R, Martin J, Humphries S and Montgomery H, Human angiotensin I-converting enzyme gene and endurance performance, J. Appl. Physiol. 1999; 87: 1313-1316 https://doi.org/10.1152/jappl.1999.87.4.1313
  19. Odawara M, Matsunuma A and Yamashita K, Mistyping frequency of the angiotensin-converting enzyme polymorphism and an improved method for its avoidance, Hum. Genet. 1997; 100: 163-166 https://doi.org/10.1007/s004390050484
  20. Rankinen T, Perusse L, Borecki I, Chagnon YC, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Rao DC and Bouchard C, The Na(+)-K(+)ATPase alpha2 gene and trainability of cardiorespiratory endurance: the HERITAGE Family Study, J. Appl. Physiol. 2000; 88: 346-351 https://doi.org/10.1152/jappl.2000.88.1.346
  21. Rankinen T, Perusse L, Rauramaa R, Rivera MA, Wolfarth B and Bouchard C, The human gene map for performance and health-related fitness phenotypes, Med. Sci. Sports Exerc. 2001; 33: 855-867 https://doi.org/10.1097/00005768-200106000-00001
  22. Rankinen T, Wolfarth B, Simoneau J-A, Maire-Lenz D, Rauramaa R, Rivera MA, Boulay MR, Chagnon YC, Perusse L, Keul J and Bouchard C, No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status, J. Appl. Physiol. 2000; 88: 1571-1575 https://doi.org/10.1152/jappl.2000.88.5.1571
  23. Raynolds MV, Bristow MR, Bush E, Abraham WT, Lowes BD, Zisman LS, Taft CS and Perryman MB, Angiotensin-converting enzyme DD genotype in patients with ischaemic or idiopathic dilated cardiomyopathy, Lancet 1993; 342: 1073-1075 https://doi.org/10.1016/0140-6736(93)92061-W
  24. Rigat B, Hubert C, Corvol P and Soubrier F, PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCPI) (dipeptidyl carboxypeptidase I), Nucl. Acids Res. 1992; 20: 1433
  25. Rivera MA, Dionne FT, Simoneau JA, Perusse L, Chagnon M, Chagnon Y, Gagnon J, Leon AS, Rao DC, Skinner JS, Wilmore JH and Bouchard C, Muscle-specific creatine kinase gene polymorphism and $VO_{2max}$ in the HERITAGE Family Study, Med. Sci. Sports Exerc. 1997; 29: 1311-1317 https://doi.org/10.1097/00005768-199710000-00006
  26. Rivera MA, Perusse L, Simoneau JA, Gagnon J, Dionne FT, Leon AS, Skinner JS, Wilmore JH, Province M, Rao DC and Bouchard C, Linkage between a muscle-specific CK gene marker and V02max in the Heritage Family Study, Med. Sci. Sports Exerc. 1999; 31: 698-701 https://doi.org/10.1097/00005768-199905000-00012
  27. Rivera MA, Wolfarth B, Dionne FT, Chagnon M, Simoneau JA, Boulay MR, Song TM, Perusse L, Gagnon J, Leon AS, Rao DC, Skinner JS, Wilmore JH, Keul J and Bouchard C, Three mitochondrial DNA restriction polymorphisms in elite endurance athletes and sedentary controls, Med Sci Sports Exerc 1998; 30: 687-690 https://doi.org/10.1097/00005768-199805000-00007
  28. Samani NJ, Thompson JR, O.Toole L, Channer K and Woods KL, A meta-analysis of the association of the deletion allele of the angiotensin -converting enzyme gene with myocardial infarction, Circulation 1996; 94: 708-712 https://doi.org/10.1161/01.CIR.94.4.708
  29. Sambrook J, Fritsch EF and Maniatis T (1989): Molecular Cloning-a Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor NY, pp 9.16-9.23
  30. Schunkert H, Hense H-W, Holmer SR, Stender M, Perz S, Keli U, Lorell BH and Riegger GAJ, Association between a deletion polymorphism of the angiotensinconverting-enzyme gene and left ventricular hypertrophy, N. Engl. J. Med. 1994; 330: 1634-1638 https://doi.org/10.1056/NEJM199406093302302
  31. Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G and Gorvol P. Two putative active centers in human angiotensin I -converting enzyme revealed by molecular cloning, Proc. Nat!. Acad. Sci. USA 1988; 85:9386-9390 https://doi.org/10.1073/pnas.85.24.9386
  32. Taylor RR, Mamotte CDS, Fallon K and van Bockxmeer FM, Elite athletes and the gene for angiotensin-converting enzyme, J. Appl. Physiol. 1999; 87: 1035-1037 https://doi.org/10.1152/jappl.1999.87.3.1035
  33. Tiret L, Kee F, Poirier O, Nicaud V, Lecerf F, Evans A, Cambou JP, Arveiler D, Lue G, Amouyel P and Cambien F, Deletion polymorphism in angiotensin -converting enzyme gene associated with parental history of myocardial infarction, Lancet 1993; 341: 991-992 https://doi.org/10.1016/0140-6736(93)91075-W
  34. Tiret L, Rigat B, Visvikis S, Breda C, Corvol O, Cambien F and Soubrier F, Evidence from combined segregation and linkage analysis that a variant of the angiotensin lconverting enzyme (ACE) gene controls plasma ACE, Am. J. Hum. Genet. 1992; 51: 197-205
  35. Wolfarth B, Rivera MA, Oppert JM, Boulay MR, Dionne FT, Chagnon M, Gagnon J, Chagnon Y, Perusse L, Keul J and Bouchard C, A polymorphism in the alpha2aadrenoceptor gene and endurance athlete status, Med. Sci. Sports Exerc. 2000; 32: 1709-1712 https://doi.org/10.1097/00005768-200010000-00008
  36. Woods DR, Brull D and Montgomery HE, Endurance and the ACE I/D polymorphism, Sci. Prog. 2000; 83: 317-336
  37. Woods DR, Hickman M, Jamshidi Y, Brull D, Vassiliou V, Johns A, Humphries S and Montgomery HE, Elite swimmers and the D allele of the ACE I/D polymorphism, Hum Genet 2001; 108: 230-232 https://doi.org/10.1007/s004390100466