Environmental Mutagens and Carcinogens (한국환경성돌연변이발암원학회지)
- Volume 22 Issue 4
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- Pages.319-323
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- 2002
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- 1225-6307(pISSN)
Genotoxicity study of Aralia elata extract in bacterial and mammalian cell system
두릅나무 추출물의 유전독성평가
Abstract
In order to investigate the safety of Aralia elata extract causing the reduction in the blood glucose level and oxidative stress in diabetes animals, these genotoxicity studies in bacterial and mammalian cell assay system such as Ames bacterial reverse mutation test and chromosomal aberration assay were performed. As results, in Ames bacterial reversion assay the extract in the range of 5,000-625 ug/plate did not induce mutagenicity in Salmonella typhimurium TA 98, TA 100, TA 1535 and TA 1537 strains with and without metabolic activation of S-9 mixture. For chromosomal aberration assay,