한국환경성돌연변이발암원학회지 (Environmental Mutagens and Carcinogens)

한국환경성돌연변이발암원학회 (Korean Environmental Mutagen Society)
권호 표지

The Case-Control Studies Between The Single Nucleotide Polymorphisms of the Human SA and MTHFR Gene and Hypertension in Korean Population

  • Kang, Byung-Yong (Research Institute for Life Science, Sahmyook University) ;
  • Bae, Joon-Seol (Seoulin Bioscience Institute, Seoulin Bioscience, Co., Ltd) ;
  • Kim, Ki-Tae (Seoulin Bioscience Institute, Seoulin Bioscience, Co., Ltd) ;
  • Lee, Kang-Oh (Department of Life Science, Sahmyook University) ;
  • Kang, Chin-Yang (Department of Pharmacy, Sahmyook University) ;
  • Chung, Ki-Wa (Department of Biology and Institute of Biotechnology, Kongju National University) ;
  • Oh, Sang-Duk (College of Physical Education, Hanyang University)
  • 발행 : 2002.09.01
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초록

The role of the kidney in initiating hypertension has been much debated. The SA gene is expressed in the kidney and is association with hypertension in man and in experimental animal models. Also, increased plasma concentrations of homocysteine have been found in patients with coronary artery disease (CAD) and hypertension. The genetic variation of methlene tetrahydrofolate reductase (MTHFR) gene is related to its enzyme activity and to the plasma homocysteine concentration. In view of the effect of SA and MTHFR as risk factor for cardiovascular diseases, we investigated the Pst I RFLP of the SA gene and C667T mutation of the MTHFR gene in the Korean patients with hypertension. There were no significant differences in the allele and genotype frequencies of these polymorphisms between normotensive and hypertensive subjects. Therefore, our results do not support a possible role of these genes on hypertension in Korean population.

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