Restorative Dentistry and Endodontics

  • 제27권5호
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  • Pages.451-462
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  • 2002
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  • 2234-7658(pISSN)
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  • 2234-7666(eISSN)
대한치과보존학회 (The Korean Academy of Conservative Dentistry)
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흰쥐 삼차신경절 뉴론의 이온통로의 분포에 관한 연구

Distribution of ion channels in trigeminal ganglion neuron of rat

  • 김애경 (경희대학교 치과대학 보존학교실) ;
  • 최경규 (경희대학교 치과대학 보존학교실) ;
  • 최호영 (경희대학교 치과대학 보존학교실)
  • Kim, Ae-Kyung (Department of Conservative Dentistry, College of Dentistry, Kyung Hee University) ;
  • Choi, Kyoung-Kyu (Department of Conservative Dentistry, College of Dentistry, Kyung Hee University) ;
  • Choi, Ho-Young (Department of Conservative Dentistry, College of Dentistry, Kyung Hee University)
  • 발행 : 2002.09.01
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⟨ 이전 논문 다음 논문 ⟩

초록

삼차신경은 구강악안면영역의 운동 및 감각을 담당하고 있으므로 치과임상에서 매우 중요하다. 삼차신경근 중 삼차신경절에 세포체를 갖는 뉴론은 주로 체성 감각을 전달하는 1차 구심신경으로 악안면영역의 촉각, 압각, 진동감각 온도각 및 통각을 담당한다. 이러한 감각의 전달은 기본적으로 신경세포의 이온통로의 활동에 의존하는데 삼차신경절 세포에 여러 종류의 이온통로가 존재하는 것으로 알려져 있다. 본 연구에서는 항체 염색법을 이용하여 이온통로가 존재를 확인 하고자 한다. 횐쥐의 삼차신경절로부터 통법에 따라 뉴론을 단일 세포로 분리하고 immunocytochemistry 방법으로 세포를 염색하여 관찰한 바 다음과 같은 결과를 얻었다. 본 실험에서 이온전류의 측정 등으로 관찰된 여러 종류의 이온통로들을 면역 염색법으로 확인하였다. 횐쥐의 삼차신경절 뉴론에서 확인된 이온통로는 소디움통로와 N, P 및 Q-type의 칼슘통로 그리고 BK$_{Ca}$, Kv 4.2 및 Kir 2.1 등의 포타슘통로이었으며 이온통로의 종류에 따라 분포에 차이를 나타내었다.

키워드

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