Toxicological Research

  • 제18권2호
  • /
  • Pages.205-213
  • /
  • 2002
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

백신 접종후 발생할 수 있는 전신적과민증 예측을 위한 아급성 실험동물 모형 개발과 관련 면역독성학적 지표치 평가

Development of Subacute Animal Model to Predict Occurrence of Systemic Anaphylaxis Following Vaccination and Evaluation of Various Immunotoxicological Parameters

  • 허용 (대구가톨릭대학교 자연대학 산업보건학과) ;
  • 김광호 (대구가톨릭대학교 자연대학 생물학과)
  • Heo, Yong (Catholic University of Daegu, College of Natural Sciences, Dept. Occupational Health) ;
  • Kim, Kwang-Ho (Catholic University of Daegu, College of Natural Sciences, Dept. Biology)
  • 발행 : 2002.06.01
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초록

This study was undertaken to develop a subacute murine model for predicting occurrence of systemic anaphylaxis and to evaluate efficacy of various immunological parameters as the monitoring indices for the occurrence of anaphyalxis. The murine anaphyalxis model was developed through intraperitoneally sensitizing 100 $\mu\textrm{g}$ ovalbumin (OVA) in the presence of 1 mg alum and 300 ng cholera toxin twice a week interval followed by challenging 500 $\mu\textrm{g}$. OVA intravenously. Typical anaphylaxis symptoms were demonstrated at the both BALB/c mice, a strain prone to type-2 response, and C57BL/6 mice. a strain prone to type-1 response. Level of plasma histamine was approximately 50-fold or 30-fold higher in the mice sensitized with OVA than the mice sensitized with alum plus cholera toxin or the saline-treated mice after OVA challenge, respectively. Sensitization and challenge with OVA significantly enhanced plasma leukotriene $B_4$ level but not IgE levels in comparison with the control mice, which indicated the role of leukotriene $B_4$ for progression of anaphyalxis. Furthermore, among mice suffered from anaphylaxis, levels of OVA-specific IgGl were significantly higher in the BALB/c mice than in the C57BL/6 mice, which implied the genetic susceptibility for the induction of systemic anaphylaxis. Conclusively, simultaneous evaluation of histamine, leukotriene $B_4$, and allergen-specific IgG isotype may serve as more efficient monitoring tool for vaccine-related anaphyalxis.

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