Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
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Synthesis and Degradation Behaviors of PEO/PL/PEO tri-block Copolymers

  • Lee, Soo-Hong (Department of Chemistry, Hanyang University) ;
  • Kim, Soo-Hyun (Biomaterials Research Center, Korea Institute of Science and Technology) ;
  • Kim, Young-Ha (Biomaterials Research Center, Korea Institute of Science and Technology) ;
  • Han, Yang-Kyoo (Korea Center for Advanced Functional Polymers, KAIST)
  • Published : 2002.04.01
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Abstract

Poly (ethylene oxide)/polylatide/poly(ethylene oxide) (PEO/PL/PEO) tri-block copolymers, which each block is connected by ester bond, were synthesized by coupling reaction of PL with PEO in the presence of pyridine. PL/PEO/PL tri-block copolymer was synthesized by ring opening polymerization of L-lactide initiated by PEO in the presence of stannous octoate. Degradation behavior of the copolymers was investigated in a pH 7.4 phosphate buffer saline (PBS) at 37$\pm$1 $^{\circ}C$. Gel permeation chromatography (GPC) and $^1$H-nuclear magnetic resonance (NMR) were used to monitor the change of mass loss, molecular weight and composition of copolymers. In hydrolytic degradation, the PEO/PL/PEO tri-block copolymer with high PEO contents affected the increase of its mass loss, and resulted in the decrease of its molecular weight as well as PEO composition. However, when PL/PEO/PL and PEO/PL/PEO tri-block copolymers had similar PEO contents, PEO/PL/PEO decreased faster in molecular weight and PEO composition than PL/PEO/PL.

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