상엽 추출물을 이용한 항당뇨 음료의 개발 (I) - 상엽 추출물의 제제화 탐색 -

Development of An Anti-Diabetic Functional Drink (I) - Screening of the Manufacturing of Mulberry Leaf Extract -

  • 구성자 (경희대학교 식품영양학과) ;
  • 윤기주 (원주국립대학 간호학과) ;
  • 김근풍 (신동방 메딕스 늘원연구소)
  • 발행 : 2002.10.01

초록

본 연구는 천연 자원인 뽕나무에서 혈당강하 효능을 가진 뽕잎(상엽)의 열수 추출법을 이용하여 상엽 추출물의 공정화 확립과 Formulation 개발을 위해 상엽 추출물과 silk peptide 및 한약재를 첨가한 시제품을 동물실험을 통하여 Formulation을 최종 결정하여 제품화하여 기능성 음료를 개발하고자 하였다. 연구 결과, 상엽 추출의 최적 조건은 상엽 크기는 3mm 이하로 하고, 2/3 정도 packing된 면포자루로 포장된 상엽을 사용하며, 상엽 사용량은 50~100 g/L, 추출 온도는 9$0^{\circ}C$, 추출 시간은 2 hr으로 하였으며 이때 수율은 20~25%였다. 또한 시료 배합에 따른 혈당강하 실험을 통하여 상엽 추출물과 silk peptide 의 농도는 각각 1%, 0.1%일 때 혈당강하 작용이 가장 우수하였으며 부재료로 사용된 둥글레는 상엽추출물의 10% 첨가한 경우가 혈당강하작용이 가장 컸으며, polydextrose도 효과가 있으므로 첨가하는 것이 바람직하다고 사료된다.

Mulberry leaves are believed to be a potent inhibitor of intestinal $\alpha$-glycosidase and the digestion of sucrose in the small intestine. Mulberry leaves are also blown to help prevent the postprandial hyperglycemia. The objective of this study was to elucidate the functionality and anti-hyperglycemic effect of mulberry leaves, and to develop a functional drink using mulberry leaf, silk peptide and oriental medicine. Several mixtures of mulberry lear extract silk peptide and oriental medicine were made for the purpose of manufacture and formulation of products. These mixtures were tested to check the $\alpha$-glycosidase inhibition effect to find the best formula. The optimum conditions for a mulberry leaf hot water extract were that the size of leaf was under 3mm, the amount of leaf needed 50~100 g/L, extraction temperature 9$0^{\circ}C$ and extraction time 2 hr. The yield of extraction was 20~25%. The anti-hyperglycemic effect of mulberry leaves was at maximum when the concentrations of mulberry leaf extract and silk peptide were 1% and 0.1%, respectively.

키워드

참고문헌

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