Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effect of Dietary Iron and Coffee Intake on Oxidative Stress and Antioxidative Enzyme Activities of Rats

식이 철 수준과 커피 섭취가 흰쥐의 산화스트레스와 항산화효소 활성에 미치는 영향

  • 김혜영 (용인대학교 식품영양학과) ;
  • 정현선 (용인대학교 식품영양학과)
  • Published : 2002.11.01
Download PDF
⟨ Previous Next ⟩

Abstract

Iron deficiency is a severe nutritional problem in the world. Coffee intake of the people is increasing every year and it can increase the loss of several essential body minerals including iron. Either iron deficiency or coffee intake may increase the oxidative stress of the body. However, the effect of iron deficiency and/or coffee intake on peroxidation have not been studied much. Therefore, the aim of this study was to investigate the effect of coffee intake on oxidative stress and antioxidative enzyme activities of iron-deficient rats. Forty-eight male rats of Sprague-Dawley strain were divided into two groups by dietary iron levels. Iron deficient group were fed 5 ppm iron diet and iron-sufficient group were fed 50 ppm iron diet. Each iron group were divided into three sub-groups by coffee levels (0%, 1%, 4%) included in the experimental diet. The experimental diets were fed for 4 weeks. The hemoglobin level was significantly low in iron deficient group and the level was exacerbated by high coffee intake. The malondialdehyde concentration of the plasma and liver were not affected by iron or coffee level in this study. However, plasma aspartate aminotransferase and alanine aminotransferase, the indicator of the liver damage, were increased by high coffee intake. The erythrocyte and liver superoxide dismutase (SOD) activities were elevated in iron deficient groups. Coffee intake increased erythrocyte SOD activity in iron sufficient groups. Glutathione peroxidase and catalase activities were not influenced much by either iron or coffee intake. In conclusion, high coffee intake in iron deficiency may not only increase the anemia symptoms, but also may increase the oxidative stress of the body.(Korean J Nutrition 35(9) : 919~925, 2002)

Keywords

References

  1. J Nutr v.116 Coffee intake during pregnancy and lactation in rats: maternal dnd pup hematological parameters and liver iron, zinc, and copper concentration Munoz L;Keen CL;Lonnerdal B;Deway K.
  2. Nutr Rev v.36 no.4 Caffeine-its identity, dietary sources, intake and biological effects Graham DM. https://doi.org/10.1111/j.1753-4887.1978.tb03717.x
  3. J Chromatogram v.342 Improved HPLC method for the simultaneous determination of caffeine and its N-demethlated metabolites in plasma using solid-phase extraction Harthley. R;Smith LJ;Cookman JR.
  4. J Chromatogram v.375 Determination of the urimary metabolites of caffeine and the opilline by HPLC Scotl NR;Chakraborty J;Marks V. https://doi.org/10.1016/S0378-4347(00)83724-X
  5. Korean J Nutr v.26 no.9 Macro mineral responses to caffeine in serum and urine of healthy young females (I) Im SA;Rho SN.
  6. Am J Clin Nutr v.37 Inhibition of iron absorption by coffee Mork TA;Lynch SR;Cook JD.
  7. Occurrence, causes and prevention of nutritional anemias Iron in man Bothwell TH;Finch CA;Blix G(ed.)
  8. Modren nutrition in health and disease(8th ed.) Iron in medicine and nutrition Fairbanks VF.;Shils Me(ed.)
  9. Textbook of clinical chemistry Biochemical aspets of hematology Fairbanks VS;Klee GG;Tietz NW(ed.)
  10. Korean J Community Nutr v.1 no.1 Nutritional status of iron, zinc and coper of preschool children residing in low-income area of seoul Son SM;Park SH.
  11. Korean J Nutr v.31 no.7 The effect of iron supplementation on the hematological iron status and Pb and Cd levels in erythrocyte, hair and urine of subjects with suboptimal iron status Son SM;Jung HY.
  12. Korean J Community nutr v.2 no.1 Iron nutritional status of female students in Kangnung National University Lee KH;Kim EK;Kim MK.
  13. J Korean Soc Food Sci Nutr v.28 no.5 A study on iron status and anemia of female college students of Ulsan city Hong SM;Kim EY;Kim SR.
  14. Blood v.68 The liabilities of iron deficiency Cook JD;Lynch SR.
  15. Nutrient Requirements of Laboratory Animals(3rd ed.) no.10 National Research Council.
  16. Method in enzymology v.105 Assay for blood plasma or serum Yagi K. https://doi.org/10.1016/S0076-6879(84)05042-4
  17. J Nutr v.115 Effect of dietary polyunsaurated/saturated fatty acid ratio and dirtary vitamin E on lipid peroxidation in the rat Buckingham KW.
  18. J Lab Clin Med v.35 The estimation of red cell superoxide dismutase activity Winterbourn CC;Hawkins RE;Brian M;Carrell RW.
  19. J Lab Clin Med v.70 no.1 Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase Paglia DE;Valentine WN.
  20. Analytical Biochem v.174 A spectrophotometric method of determination of catalase activity in small tissue samples Johansson LH;hankan Borg LA. https://doi.org/10.1016/0003-2697(88)90554-4
  21. J Nutr v.177 Iron intake influences essential fatty acid and lipid composition of rat plasma and erythrocytes cunnane SC;Mcadoo KR.
  22. J Nutr v.129 no.7 Dietray copper primarily affects antioxidant capacity and dietary iron mainly affects iron status in a surface response study of female rats fed varying concentrations of iron, zinc copper Roughhead ZK;Johnaon LK;Hunt JR.
  23. Master's thesis. Ewha Womans University Effect of different dietary protein level and source with supplemental coffee on lipid metabolism of rats Lee HW.
  24. Master's thesis. Ewha womans University Effect of different dietary fat level and source with supplemental coffee on lipid metabolism of rats Jung JI.
  25. J Clin Nutr v.37 Inhibition of food iron absorption by coffee Mock Ta;Lynch SR;Cook JD
  26. Korean J Nutr v.29 no.7 Effects of caffeine intake levels on iron metabolism in male and female rats Park SJ;Sung CJ.
  27. Master's thesis. Kyungbook national University Changes in lipid and protein composition of rat blood, liver tissue, and cultured cells with supplemental feeding of caffeine, iron and vitamin E Do JC.
  28. Res Commun Mol Pathol Pharmacol v.97 no.3 Dietary iron alters liver, erythrocyte and plasma antioxidant and nitrite levels and also sensitizes the heart to ischemia/reperfusion van Jaarsveld H;Schulenburg DH.
  29. J Nutr v.127 no.7 Oxidative sress and antioxidant status in mouse liver: effects of dietary lipid, vitamin E, and iron Ibrahim W;Lee US;Yeh CC;Szabo J;Bruckner G;Chow CK
  30. J Nutr v.130 Both iron deficiency and daily iron supplements increase lipid peroxidation in rats Knutson MD;Walter PB;Ames BN;Biteri FE.
  31. The extra pharmacopoeia(29th ed.) James EF.
  32. J Appl Physiol v.54 no.5 Effect of caffeine on skeletal muscle function before and after fatigue Lopes JM;Aubier M;Jardim J;Aranda V;Macklem PT.
  33. J Chormatogram v.375 Determination of the urimary metabolites of caffeine and theophilline by HPLC Scott NR;Chakraborty J;Marks V. https://doi.org/10.1016/S0378-4347(00)83724-X
  34. Biol Trace Elem Res v.50 no.3 Effect of dietary caffeine and zinc on the activity of antioxidant enzymes, zinc, and copper concentration of the heart and liver in fast-growing rats Rosso MJ;Ghanaei P;Nakamoto T. https://doi.org/10.1007/BF02785413