Biomedical Science Letters (대한의생명과학회지)
- Volume 8 Issue 3
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- Pages.115-125
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- 2002
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- 1738-3226(pISSN)
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- 2288-7415(eISSN)
Hematological Aspects in A Endotoxemic Young Rabbit Model
- Park, Seok-Cheol (Department of Clinical Laboratory Science, College of Health Science, Catholic University of Pusan) ;
- Kwon, Heun-Young (Department of Clinical Laboratory Science, College of Health Science, Catholic University of Pusan) ;
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Kim, Jai-Young
(Department of Clinical Laboratory Science, College of Health Science, Catholic University of Pusan) ;
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Hwang, Soo-Myung
(Department of Clinical Laboratory Science, College of Health Science, Catholic University of Pusan) ;
- Kim, Tae-Un (Department of Clinical Laboratory Science, College of Health Science, Catholic University of Pusan) ;
- Seong, Hee-Kyung (Department of Medical Laboratory Science, InJe University) ;
- Kim, Yang-Weon (Department of Emergency Medicine, Pusan Paik Hospital, College of Medicine, Inje University) ;
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Lee, Won-Jae
(Department of Microbiology, Pukyong National University)
- Published : 2002.09.01
Abstract
Gram-negative septicemia, which continues to be a serious clinical problem, is one of the major causes of morbidity and mortality in hospitalized patients. Endotoxin of gram-negative bacteria is a pivotal pathogen of sepsis. To understand the effect of endotoxin on hematological aspect and the time course in early childhood, this study was designed with experimental septic model of young rabbits (8 week-old). Rabbits were divided into control (n=7) and endotoxin group (0.50 mg/kg of endotoxin). The endotoxin group was subdivided into six groups by the sampling times: 3, 6, 12, 24, 48 and 72 hr-group (E-G