한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제19권3호
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  • Pages.312-315
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  • 2002
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

임상진단 검사에서 ROC 곡선의 응용

Application of Receiver Operating Characteristics (ROC) Curves for Clinical Diagnostic Tests

  • Pak, Son-Il (Department of Veterinary Medicine, Kangwon National University) ;
  • Koo, Hee-Seung (College of National Resources, Colorado State University) ;
  • Hwang, Cheol-Yong (College of Veterinary Medicine, Seoul National University) ;
  • Youn, Hwa-Young (College of Veterinary Medicine, Seoul National University)
  • 발행 : 2002.09.01
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초록

질병에 이환된 개체로부터 이환되지 않은 개체를 구분하기 위해 사용되는 대부분의 진단검사는 판별의 기준점 (cut-off value)을 필요로 한다. ROC (receiver operating characteristic) 곡선은 이러한 목적으로 흔히 사용되고 있으며 진단의 기준점을 다양하게 변화시킬 때 진단검사의 정확도 (민감도와 특이도)를 제시해주는 지표로 활용되고 있다. 저자들은 수의학관련 연구자들이 이 방법을 효과적으로 사용할 수 있도록 EXCEL에 내장된 비쥬얼 베이직으로 binormal ROC 곡선의 최대우도비를 계산해주는 프로그램을 작성하였다. 방사선 분야의 자료와 미생물학 자료를 예제로 들어 이 프로그램의 활용성을 높이고자 하였고 이 분야에 관심이 있는 연구자는 저자에게 연락하여 이 프로그램을 얻을 수 있다.

Diagnostic tests often require the determination of cut-off values that discriminate uninfected from infected individuals. The receiver operating characteristic (ROC) curve has been frequently used to attain this purpose and gives a representation of diagnostic accuracy (sensitivity and specificity) of a prediction model when varying the cut-point of a decision rule on a whole spectrum. We have written and tested a visual basic application program in EXCEL for maximum likelihood estimation of a binormal ROC curve, which also computes univariate statistics of a diagnostic test employed. Examples applying for computed tomographic images in radiology and methicillin-resistant Staphylococcus aureus research are given to illustrate this approach. This stand-alone module is available from the first author on request.

키워드

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