DOI QR코드

DOI QR Code

Identification and Biological Characteristics of an Antifungal Compound Extracted from Cocklebur (Xanthium strumarium) against Phytophthora drechsleri

  • Kim, Dong-Kil (Research Institute of Life Science, Gyeongsang National University) ;
  • Shim, Chang-Ki (Research Institute of Life Science, Gyeongsang National University) ;
  • Bae, Dong-Won (Central Laboratory, Gyeongsang National University) ;
  • Kawk, Yeon-Sik (Kumho Life and Environmental Science Laboratory, Kwangju) ;
  • Yang, Min-Suk (Department of Agricultural Chemistry, Gyeongsang National University) ;
  • Kim, Hee-Kyu (Department of Agricultural Biology, Gyeongsang National University)
  • Published : 2002.01.01

Abstract

Crude extract of Xanthium strumarium inhibited mycelial growth and zoospore germination of Phytophthora drechsleri, the causal agent of Atractylis rot, in vitro. Fresh sap from X. strumarium at 50-fold dilution was highly effective in controlling the disease Incidence in pot and field trials. Purified extracts from cocklebur Inhibited mycelial growth and zoospore germination in vitro at a concentration of 12.5 $\mu\textrm{g}$/ml and 15.6 $\mu\textrm{g}$/ml, respectively. Hyphal tips affected by the compound showed malformation. The antifungal compound puri- fied fromX. strumarium was identified as 4-oxo-1 (5), 2,11, (13)-xanthatriene-12,8-olide, known as "deacetyl xanthumin".min".uot;.

Keywords

References

  1. Agata, I., Goto, S., Hatano, T, Nishibe, S. and Okuda, T. 1993.1,3,5-Tri-O-caffeoylquinic acid from Xanthium strumarium. Phytochemistry 33:508-509 https://doi.org/10.1016/0031-9422(93)85551-2
  2. Cavallito, C. J., Buck, J. S. and Suter, D. M. 1944. Allium, the antibactehal principles of Allium sativum. II. Determinationm of the chemical structure. J. Am. Chem. Soc. 66:1952-1954 https://doi.org/10.1021/ja01239a049
  3. Chang, T. T. and Ko, W. H. 1990. Resistance to fungicides and antibiotics in Phytophthora parasitica: Genetic nature and use in hybrid determination. PhytopathoIogy 80:1414-1421 https://doi.org/10.1094/Phyto-80-1414
  4. Chang, T. T. and Ko, W. H. 1992. Variation in growth rate and colony morhphology of Phytophthoraparasitica induced by metalaxyl. Ann. Phytopath. Soc. Japan 58:72-77 https://doi.org/10.3186/jjphytopath.58.72
  5. Chen, C. P., Lin, C. C. and Namba, T. 1987. Development of natural crude drug resources from Taiwan (VI). In vitro studies of the inhibitory effect on 12 microorganisms. Shoyakugaku Zasshi 41:215-225
  6. Coffey, M. D. and Bower, L. A. 1984. In vitro variability among isolates of six Phytophthora species in response to metalaxyl. Phytopathotogy 74:502-506 https://doi.org/10.1094/Phyto-74-502
  7. Cohen, Y., Reuveni, M. and Eyal, H. 1979. The systemic antifun-gal activity of ridomil against Phytophthora infestans on tomato plants. Phytopathotogy 69:645-649 https://doi.org/10.1094/Phyto-69-645
  8. Cole, R. J., Stuart, B. R, Lansden, J. A. and Cox, R. H. 1980. Isolation and redefinition of the toxic agent from cocklebur (Xanthium strumarium). J. Agri. Food Chemistry 28:1330-1332 https://doi.org/10.1021/jf60232a043
  9. Cutler, H. G. and Cole, R. J. 1983. Carboxyatractyloside: a compound from Xanthium strumarium and Atractytis gummifera with plant growth inhibiting properties. The possible 'inhibitor A'. J. Naturat Products 46:609-613 https://doi.org/10.1021/np50029a003
  10. Hamm, P. B., Cooley, S. J. and Hansen, M. 1984. Response of Phytophthora spp. to metalaxyl in forest tree nursehes in the Pacific Northwest. PtantDis. 68:671-673 https://doi.org/10.1094/PD-69-671
  11. Jang, D. S. 1998. Biological activities of sesquiterpene lactones isolated from Hemisteptia lyrata Bunge, Chrysanthemum zawadskii Hirbich var. latitobum Kitamura and Chrysanthemum boreate Makino. Gyeongsang National University Ph.D thesis. 191 p
  12. Joseph, M. C. and CotFey, M. D. 1984. Development oflaboratory resistance to metalaxyl in Phytophthora citricola. Phytopathology 74:1411-1414 https://doi.org/10.1094/Phyto-74-1411
  13. Kim, D. K., Jee, H. J. and Kim, H. K. 1997. Occurrence of rhizome rot of Atractytodes spp. caused by Phytophthora drechsteri. Korean J. Ptant Pathol. 13:433-437
  14. Malik, M. S., Sangwan, N. K. and Dhindsa, K. S. 1993. Xanthanolides from Xanthium strumarium. Phytochemistry 32:206-207 https://doi.org/10.1016/0031-9422(92)80135-2
  15. Marco, J. M., Sanz-Cervera, J. E, Corral, J., Carda, M. and Jak-upovic, J. 1993. Xanthanolides from Xanthium: absolute configuration of xanthanol, isoxanthanol and their C-4 epimers. Phytochemistry 34:1569-1576 https://doi.org/10.1016/S0031-9422(00)90847-1
  16. McMillan, C., Mabry, T. J. and Chavez, P. I. 1976. Experimental hybridization of Xanthium strumarium (Compositae) from Asia and America, 2: Sesquiterpene lactones of Fl hybrids.American J. Botany 63:317-323 https://doi.org/10.2307/2441576
  17. Minato, H. and Horibe, I. 1965. Studies on sesquiterpenoids XI. Structure and stereochemistry of xanthumin, a stereoisomer ofxanthinin. J. Chem. Soc. 1965:7009-7019
  18. Ohmoto, T., Kano, M., Koike, K., Hitokoto, H. and Morozumi, S.1981. Antimycotic substance in the crude drugs. Shoyakugaku Zasshi 35:71-77
  19. Ohmoto, T. and Sung, Y. I. 1982. Antimycotic substances in the crude drugs II. Shoyakugaku Zasshi 36:307-314
  20. Paik, S. B., Chung, I. M. and Doh, E. S. 1998. Screening of medicinal plants with antifungal activity on major seedboorne disease. Korean J. Medicinat Crop Sci. 64:277-285
  21. Powell, C. R. and Ko, W. H. 1986. Screening for antagonistic plants for control of Phytophthora patmivora in soil. Ann. Phytopathot. Soc. Japan 52:817-824 https://doi.org/10.3186/jjphytopath.52.817
  22. Reuter, H. D. and Sendl, A. 1994. Allium sativum and Allium ursinum: Chemistry, Pharmacology and medicinal applications. In: Economic and Medicinat PIant Reaserch Vol.6, edited by Wagner, and Famsworth, N. R. Published by Academic Press. 55-11
  23. Saxena, V. K. and Mondal, S. K. 1994. A xanthanolide from Xanthium strumarium. Phytochemistry 35:1080-1082 https://doi.org/10.1016/S0031-9422(00)90678-2
  24. Stoll, A. and Seebeck, E. 1948. Uber Alliin, die genuine Muttersubstanz des Knoblauchols. 1. Mitteilung uber Allium-Substanzen. Helv. Chim. Acta 31:189-210 https://doi.org/10.1002/hlca.19480310140
  25. Yoshida, S., Kasuga, S., Hayashi, N., Ushiroguchi, T., Matsuura, H. and Nakagawa, S. 1987. Antifungal activity of ajoene derived from garlic. Appl. Environ. Microbiol. 53:615-617

Cited by

  1. Control of foliar diseases of tea with Xanthium strumarium leaf extract vol.37, pp.1, 2012, https://doi.org/10.1016/j.indcrop.2011.12.030
  2. Xanthane sesquiterpenoids: structure, synthesis and biological activity vol.28, pp.4, 2011, https://doi.org/10.1039/c0np00011f
  3. Inhibitory effect of some plant crude extracts against cucumber damping-off agents vol.41, pp.3, 2012, https://doi.org/10.1007/s13313-012-0129-3
  4. Xanthium strumariumL. Extracts Produce DNA Damage Mediated by Cytotoxicity inIn VitroAssays but Does Not Induce Micronucleus in Mice vol.2014, 2014, https://doi.org/10.1155/2014/575197
  5. In vitroEffects of Plant Extracts, and Phytohormones on Mycelial Growth of Anthracnose Fungi vol.32, pp.3, 2004, https://doi.org/10.4489/MYCO.2004.32.3.134
  6. Traditional Uses, Botany, Phytochemistry, Pharmacology, Pharmacokinetics and Toxicology of Xanthium strumarium L.: A Review vol.24, pp.2, 2019, https://doi.org/10.3390/molecules24020359