Animal cells and systems

  • 제6권3호
  • /
  • Pages.187-193
  • /
  • 2002
  • /
  • 1976-8354(pISSN)
  • /
  • 2151-2485(eISSN)
한국통합생물학회 (The Korean Society for Integrative Biology)
권호 표지

Radiation Hormesis： Incredible or Inevitable\ulcorner

  • Ducoff, Howard-S (Department of Molecular and Integrative Physiology and Center for Biophysics and Computational Biology, University of Illinois)
  • 발행 : 2002.09.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

It has long been recognized that exposure to low levels of toxic chemicals could have beneficial effects, such as increased resistance to related chemicals or stimulation of growth or development. The notion of radiation hormesis, that exposure to low levels of ionizing radiation could produce beneficial effects, developed seriously in the late 1950’s, and was, to most radiation scientists, incredible. This was due in pan to the then prevailing ideas of radiobiological mechanisms, in part to the sweeping generalizations made by the leading proponents of the radiation hormesis concept, and in pan to the many failures to confirm reports of beneficial effects. More recent understanding of the mechanisms of radiation damage and repair, and discoveries of induction of gene expression by radiation and other genotoxic agents [the adaptive response] make it seem inevitable that under suitable conditions, irradiation will produce beneficial effects.

키워드

참고문헌

  1. Allen RG and Sohal RS (1982) Life-shortening effects of gamma-radiation on the adult hosefly, Musca Domestica, Mech Aging Devel 20: 369-375 https://doi.org/10.1016/0047-6374(82)90104-X
  2. Baxter RC and Blair HA (1969) Recovery and over-recovery from acute radiation injury as a function of age in Drosophila, Radiat Res 39: 345-360 https://doi.org/10.2307/3572671
  3. Bhatnagar PL, Rockstin M and Dauer M (1965) X-Irradiation of the house fly, Musca Domestica, and adult survival, Exp Gerontol, 1: 149-159 https://doi.org/10.1016/0531-5565(65)90018-5
  4. Calabrese EJ and Baldwin LA (2000a) Chemical hormesis: its historical foundations as a biological hypothesis, Hum Exp Toxicol 19: 2-31 https://doi.org/10.1191/096032700678815585
  5. Calabrese EJ and Baldwin LA (2000b) Radiation hormesis: the demise of a legitimate hypothesis, Hum Exp Toxicol 19: 76-84 https://doi.org/10.1191/096032700678815611
  6. Cork JM (1957) Gamma-radiation and longevity of the flour beetle, Radiat Res 7: 551-557 https://doi.org/10.2307/3570571
  7. Curtis HJ (1966) Biological Mechanisms of Aging, Charles C. Thomas, Springfield II
  8. Davey WP (1917) The effect of X-rays on the length of life of Tribolium confusum, J Exp Zool 22: 573-592 https://doi.org/10.1002/jez.1400220305
  9. Davey WP (1919) Prolongation of life of Tribolium confusum apparently due to small doses of X-rays, J Exp Zool 20: 447-458 https://doi.org/10.1002/jez.1400280305
  10. Ducoff HS (1972) Causes of death in irradiated adult insects, Biol Rev 47: 211-240 https://doi.org/10.1111/j.1469-185X.1972.tb00973.x
  11. Ducoff HS (1975) Form of the increased longevity of Tribolium after X-irradiation, Exp Gerontol 10: 189-193 https://doi.org/10.1016/0531-5565(75)90031-5
  12. Ducoff HS (1976) Radiation-induced increase in life span of insects. Implications for theories of mammalian aging and radiosensitivity, In: Anon (ed.) Biological and Environmental Effects of Low-Level Radiation, Vol II, International Atomic Energy Agency, Vienna, pp. 103-109
  13. Ducoff HS (1986) Radiation and longevity enhancement in Tribolium. In: Collatz K-G and Sohal RS (eds) Insect Aging,. Springer-Verlag, Berlin, pp 73-89
  14. Ducoff HS and Lee YJ (1984) Radiation-induced resistance to heat and to oxygen, Overgaard J (ed.) Hyperthermic Oncology 1984, Taylor and Francis, London, pp. 297-300
  15. Elkind MM and Hutton H (1959) X-Ray damage and recovery in mammalian cells in culture, Nature 184: 1293-1295 https://doi.org/10.1038/1841293a0
  16. Fornace AJJ (1992) Mammalian genes induced by radiaton. Activatioln of genes associated with growth control, Annu Rev Genet 26: 507-526 https://doi.org/10.1146/annurev.ge.26.120192.002451
  17. Fornace AJJ, Jackman J, Hollander MC, Hoffman-Libemann B, and Liebermann DA (1992) Genotoxic-stress-response genes and growth-arrest genes-gadd, MyD, and other genes induced by treatments eliciting grpwth arrest, Ann NY Acad Sci 663: 139-153 https://doi.org/10.1111/j.1749-6632.1992.tb38657.x
  18. Fornace AJJ, Schal H and Alamo JJ (1988) Coordinate induction of metallothioneins I and II in rodent cells by UV irradiation, Mol Cell Biol 8: 4716-4720 https://doi.org/10.1128/MCB.8.11.4716
  19. Hart RW and Setlow RB (1974) Correlation between deoxyribonucleic acid excision-repair and life-spanin a number of mammalian species, Proc Natl Acad Sci USA 70: 2169-2173
  20. Hollander MC and Fornace AJJ (1989) Induction of fos RNA by DNA-damaging agents, Cancer Res 49: 1687-1692
  21. Howard A and Cowie FG (1976) Induced resistance in a desmid Closterium monilife rum, Radiat Res 65: 540-549 https://doi.org/10.2307/3574385
  22. Jones DCL and Kimeldorf DJ (1964) Effect of age at irradiation on the life span of the male rat, Radiat Res 22: 106-115 https://doi.org/10.2307/3571700
  23. Kruger JH and Walker G (1984) groEL and dnaK genes of Escherichia coli are induced by UV irradiation and nalidixic acid in $htpR^+$-dependent fashion, Proc Natl Acad Sci USA 81: 1499-1503 https://doi.org/10.1073/pnas.81.5.1499
  24. Lamb MJ (1965) The effects of X-irradiation on the longevity of triploid and diploid female Drosophila melanogaster, Exp Gerontol 1: 181-187 https://doi.org/10.1016/0531-5565(65)90001-X
  25. Lamb MJ (1978) Aging In: Ashburner M and Wright TRF (eds)The Genetics and Biology of Drosophila, Vol. 2C, Academic Press London, pp. 43-104
  26. Lea DE (1947) Actions of Radiations on Living Cells, MacMillan, New York
  27. Lee YJ and Ducoff HS (1983) Age and sensitivity to oxygen in the flour beetl, Mech age Dev 22: 97-103 https://doi.org/10.1016/0047-6374(83)90102-1
  28. Lee YJ and Ducoff HS (1984) Radiation-enhanced resistance to oxygen: a possible relationship to radiation-enhanced longevity, Mech Age Dev 27: 101-109 https://doi.org/10.1016/0047-6374(84)90087-3
  29. Luckey TD (1980) Hormesis with Ionizing Radiation, CRC Press, Boca Raton
  30. Mayanrd Smith, J (1958) Prolongation of the life of Drosophila subobscura by a brief exposure to a high temperature, Nature, 181: 496-497 https://doi.org/10.1038/181496a0
  31. Miller MW and Miller WM (1987) Radiation hormesis in plants, Health Phys 52: 607-616 https://doi.org/10.1097/00004032-198705000-00012
  32. Mitchel REJ and Morrison DP (1984) Is Is DNA Damage the Signal for Induction of Thermal Resistance? Induction by Radiation in Yeast, Radiat Res 99: 383-393 https://doi.org/10.2307/3576381
  33. Olivieri G, Bodycote J and Wolffs S (1984) Adaptive response of human lymphocytes to low concentrations of radioactive thymidine, Science 223: 594-597 https://doi.org/10.1126/science.6695170
  34. Patterson RS (1957) On the causes of broken wings of the house, J Econ Entomol 50: 104-105 https://doi.org/10.1093/jee/50.1.104
  35. Ragland SS and Sohal RS (1973) Mating behavior, physical activity and aging in the housely, Musca domesitica. Exp Gerontol 8: 135-145 https://doi.org/10.1126/science.6695170
  36. Rockstein M (1956) Some biochemical aspects of aging in insects, J Gerontol 11: 282-285 https://doi.org/10.1093/geronj/11.3.282
  37. Ruby SW and Szostac JW (1985) Specific Saccharomyces cerevisiae genes are expressed in response to DNA-damaging agents, J Gerontol 11: 282-285
  38. Sacher GA (1956) On the statistical nature of mortality with especial reference to chronic radiation mortality, Radiology 67: 250-257 https://doi.org/10.1148/67.2.250
  39. Sacher GA (1963) Effects of X-rays on the survival of Drosophila imagoes, Physiol Zool 36: 296-311
  40. Simms HS (1946) Logarithmic increase in mortality as a manifestation of aging, J Gerontol 1: 13-26 https://doi.org/10.1093/geronj/1.1_Part_1.13
  41. Skok J, Chorney W and Rakosnik EJJ (1965) An examination of stimulatory effects of ionizing radiation in plnats, Radiat Bot 5: 281-292 https://doi.org/10.1016/S0033-7560(65)80016-3
  42. Upton AC, Kimball AW, Furth J, Christenberry KW and Benedict WH (1960) Some delayed effects of atom-bomb radiations in mice, Cancer Res 20: 1-60
  43. Walburg HE Jr (1975) Radiation-induced life-shortening and premature aging, Adv Radiat Biol 5: 145-179
  44. Wolff S, Afzal V, Wiencke JK, Olivieri G and Michael A (1988) Human lymphocytes exposed to low doses of ionizing radiations become refractory to high doses of radiation as well as to chemical mutagens that induce double-strand breaks in DNA, Int J Radiat Biol 53: 39-48 https://doi.org/10.1080/09553008814550401
  45. Woloschak GE and Chang-Liu C-M (1990) Differential modulation of specific gene expression following high- and low-LET radiations, Radiat Res 124: 183-187 https://doi.org/10.2307/3577864
  46. Youngblom JH, Wiencke JK and Wolff S (1989) Inhibition of adaptive response of human lymphocytes to very low doses of ionizing radiation by the protein synthesis inhibitor cycloheximide, Mutation Res 227: 257-261 https://doi.org/10.1016/0165-7992(89)90107-3
  47. Radiat Res v.124 Differential modulation of specific gene expression following high- and low-LET radiations Woloschak GE;Chang-Liu C-M https://doi.org/10.2307/3577864
  48. Mutation Res v.227 Inhibition of adaptive response of human lymphocytes to very low doses of ionizing radiation by the protein synthesis inhibitor cycloheximide Youngblom JH;Wiencke JK;Wolff S https://doi.org/10.1016/0165-7992(89)90107-3