A Study of Nutrient Intake, Serum Lipid and Leptin Levels of Elementary School Students with Different Obesity Index in Kyunggi Area

경기지역 일부 초등학생의 성별과 비만도에 따른 영양소 섭취상태와 혈청 Leptin 및 혈청 지질에 관한 연구

  • 이윤신 (수원여자대학 식품과학부) ;
  • 박혜순 (울산의대 서울아산병원 가정의학과) ;
  • 이명숙 (성신여자대학교 식품영양학과) ;
  • 성미경 (숙명여자대학교 식품영양학과) ;
  • 박동연 (동국대학교 가정교육학과) ;
  • 최미경 (청운대학교 식품영양학과) ;
  • 김미현 (숙명여자대학교 식품영양학과) ;
  • 승정자 (숙명여자대학교 식품영양학과)
  • Published : 2002.09.01

Abstract

The purpose of this study was to investigate the relationship among nutritional status, serum lipids and leptin of 134 elementary school students with different obesity index residing in Kyunggi-do, Korea. Subjects were assigned to under weight, normal weight or over weight group according to the their obesity index. Their nutritional status, serum lipid and leptin levels were evaluated based on 24-hr dietary recalls, anthropometric measurements and blood analysis. The mean weight, height and obesity index of total subjects was 150.8cm, 45.6kg and 5.4%. The mean % of body fat was higher while LBM and TBW (total body water) were lower in over weight subjects than those of other two groups. Total food, plant protein, carbohydrate, and vitamin C intakes of underweight male students were lower than those of overweight male students. The consumption of total fat was the highest in the female normal weight subjects and the lowest in female overweight subjects. Male students consumed more plant protein and vitamin C than female students. The mean daily intake of vitamin B$_2$, calcium and zinc of all subjects did not meet the Korean RDA. Also, iron intake of female students was lower than the Korean RDA. The mean level of serum leptin was the highest in male and female overweight subjects (p<0.001). The HDL-cholesterol level was the highest in the underweight group of male subjects (p<0.05) and in the normal weight group of female subjects (p<0.001) The serum level of leptin and atherogenic index (AI) of females were higher than those of males. Serum leptin of total subjects had significantly positive correlation with obesity index, weight, SBP, body fat, cholesterol intake, serum triglyceride, and AI. However, serum leptin was negatively correlated with LBM, TBW, intake of plant protein, vitamin B$_1$, vitamin C and serum HDL-cholesterol. Obesity index was also positively correlated with weight, SBP, body fat, serum triglyceride and AI. To summarize the results, the vitamin B$_2$, calcium, zinc, iron and fiber intakes should be supplied to elementary school students, especially those who were overweight. The average serum leptin level of students showed remarkably positive correlation with obesity index, body fat, serum lipids and AI. Also, it was suggested that the serum leptin might be related to the dietary factors like cholesterol, plant protein, vitamin B$_1$ and vitamin C of elementary school students.

Keywords

References

  1. Korean J Nutrition v.26 no.2 The prevalence of obesity and it's related factors of high school girls in the large cities Kim HS;Lee LH
  2. A study of food habits, serum leptin, zinc and copper status in Korean elementary, middle and high school students with different obesity index Lee YS
  3. Kor J Dietary Culture v.10 no.1 The relationship of obesity and related behaviors among 4th and 5th Grade-Primary School Children Kim SL;Park HR
  4. Nature v.372 no.1 Positional cloning of the mouse obese gene and its human homologue Zhang Y;Proenca R;Maffei M;Barone M;Leopold L;Friedman JM https://doi.org/10.1038/372425a0
  5. Horm Rew v.46 Leptin : gene, concepts and clinical perspective Considine RV;Caro JF https://doi.org/10.1159/000185096
  6. Am J Clin Nutr v.67 Leptin and body composition of Nigerians, Jamaicans, and US blacks Luke AH;Rotimi CN;Cooper RS;Long AE;Forrester TE;Wilks R;Bennett FI
  7. Science v.269 no.28 Weight-reducing effects of the plasma protein encoded by the gene Halaas JL;Gajiwala KS;Maffei M;Cohen SL;Chait BT;Rabinowitz D;Lallone RL;Burley SK;Friedman JM https://doi.org/10.1126/science.7624777
  8. Science v.269 Effects of the obese gene product on body weight regulation in ob/ob mice Pellymounter MA;Cullen MJ;Baker MB;Hecht R;Winter D;Boone T https://doi.org/10.1126/science.7624776
  9. Clin Endocrinology v.46 Serum leptin concentrations in patients with anorexia nervosa, bulimia nervosa and non-specific eating disorders correlate with the body mass index but are independent of the respective disease Ferron F;Considine RV;Peino R;Lado IG;Dieguez C;Casanueva FF https://doi.org/10.1046/j.1365-2265.1997.1260938.x
  10. Nature Med v.1 Overexpression of the obese gene in adipose tissue of human obese subjects Lonnqvist F;Arner P;Nordfors S;Schalling M https://doi.org/10.1038/nm0995-950
  11. Nature Med v.1 Leptin levels in human and rodent measurement of plasma leptin and ob RNA in obese and weight-reduced subjects Maffei M;Halaas JL;Ravussin E;Pratley RE;Lee GH;Zhang Y;Fei H;Kim S;Lallone R;Ranganathan S;Kern PA;Friedman JM https://doi.org/10.1038/nm1195-1155
  12. J Clincal Endo Metabolism v.91 Response of leptin to short-term and prolonged overfeeding in human Kolaczynski JW;Ohannesian J;Considine RV(et al.)
  13. Food composition table(5th revision) National Rural Living Science Institute, R.D.A
  14. Clin Chem v.18 Estimation of concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Friedewald WT;Levy RI;Fredrickon DS
  15. Mayo clinic diet manual(7th ed.) Gastineau CF
  16. J Korean Pediatr Soc v.32 A study on blood pressure measurement of children in Seoul area Choi Y;Lee CY;Noh JI;Hong CE;Lee SI
  17. Recommended dietary allowances for Koreans(7th revision) The Korean Nutrition Society
  18. The study of nutritional status, serum leptin, copper and zinc contents of Korean middle school female students according to the body mass index Kim MH
  19. 95 National Nutritional Survey Report Ministry of health and welfare
  20. J Clin Invest v.95 Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity Considine RV;Considine EL;Williams CJ(et al.) https://doi.org/10.1172/JCI118007
  21. Int J Obes v.21 Leptin serum levels in normal weight and obese children and adolescents: relationship with age, sex, pubertal development, body mass index and insulin Falorni A;Bini V;Molinari D;Papi F;Celi F;Stefano GD;Berioli MG;Bacosi ML;Contessa G https://doi.org/10.1038/sj.ijo.0800485
  22. J Clin Invest v.100 no.4 Contribution of androgens to the gender difference in leptin production in obese children and adolescents Wabitsch M;Blum WF;Muche R;Braun M;Hube F;Rascher W;Heinze E https://doi.org/10.1172/JCI119595
  23. J Korean Pediatr Soc v.41 no.7 Serum leptin concentration in Korean children Choe YH;Kim SK;Hyun IY
  24. J Korean Soc Study Obesity v.7 no.4 Adipocity, metabolic parameters and circulation leptin Lee KY
  25. J Kor Soc Stu Obesity v.7 no.4 Serum leptin concentration in Korean NIDDM patients Park IB;Oh JH;Kim NH;Kim YH;Kim SJ;Baik SH;Choi DS
  26. J Kor Soc Stu Obesity v.8 no.4 A study on relationship between the adipocity and serum leptin concentration in adult women Kim EM;Cho EY;Kwon SJ;Lee JH; Song YD;Lee HC;Huh KB
  27. J Korean Soc Endocrinology v.13 no.2 Serum immunoreactive-leptin concentrations to adiposity and other biochemical parameters in Korean adults Shin JH;Nam SY;Kim ES;Kim KR;Cha BS;Song YD;Lim SK;Lee HC;Huh KB
  28. Nature v.395 no.22 Leptin and the regulation of body weight in mammals Friedman JM;Halaas JL https://doi.org/10.1038/27376
  29. Inter J Obesity v.313 Leptin in obesity Sorensen T;Echwald;Soren M;Holm;Jens C
  30. J Kor Soc Stu Obes v.8 no.2 Serum leptin levels in obses Korean adults with warying glucose tolerance;its relationship to insulin and body fat distribution Nam SY;Shin JH;Choi BK;Kim KW;Kim KR;Song YD;Lim SK;Lee HC;Huh KB
  31. Pediatrics v.98 Serum leptin in children with obesity: Relationship to gender and development Hassink SG;Sheslow DB;Lancey E;Opentanova I;Considine RV;Caro JF
  32. Korean J Community Nutrition v.2 no.2 Obesity, serum lipid and related eating behaviors of school children Son SM;Lee JH
  33. Korean J Nutr v.26 no.1 Eating behavior, Obesity and serum lipid levels in children Yim, KS;Yoon EY;Kim, CI;Kim, KT;Kim, CI;Mo, SM;Choi, HM
  34. Sookmyung university doctoral dissertation Nutritional status, immune response and trace minerals in Korean urban young women according to body mass index Lee, HO
  35. The New England J Med v.334 Serum immunoreactive-leptin concentration in normal-weight and obese humans Considine RV;Sinha MK;Heiman ML;Kriauciuas A;Stephens TW;Nyce MR;Ohannesian J;Marco GC;Makee LJ;Bauer TL;Caro JF https://doi.org/10.1056/NEJM199602013340503
  36. Rev Port Cardiol v.16 no.1 Prevalence of high blood pressure in children and adolescents, Influence of obesity Macedo ME;Ttigueiros D;De Freitas F
  37. Korean J Nutrition v.33 no.5 A study on serum leptin concentrations by obesity index in male college students in Korea Kim YS;Kim SK;Kim HJ
  38. Nat Med v.1 Leptin levels reflects body lipid content in mice: Evidence for diet-inuced resistance to leptin action Frederich RC;Hamanna A;Anderson S https://doi.org/10.1038/nm1295-1311
  39. Metabolism v.46 no.4 Effect of diet composition on leptin in lean subjects Schrauwen P;Marken LW;Westerterp KR;Saris WH https://doi.org/10.1016/S0026-0495(97)90059-7
  40. Adv Pediatr v.35 Pathophysiology of childhood obesity Rosenbaum M;Leibel RL
  41. J Kor Society Food and Nutr v.25 no.3 The relationship between serum cholesterol level and dietary intake in obese children Han JS;Rhee SH