Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Oxygen Transport in Axisymmetric Thrombosed Aneurysm

혈전이 있는 축대칭 동맥류에서의 산소전달현상

  • 김한일 (연세대학교 의공학과, 의공학연구소, 의용계측 및 재활공학 연구센터, 첨단의료기기 기술혁신센터) ;
  • 태기식 (연세대학교 의공학과, 의공학연구소, 의용계측 및 재활공학 연구센터, 첨단의료기기 기술혁신센터) ;
  • 김영호 (연세대학교 의공학과, 의공학연구소, 의용계측 및 재활공학 연구센터, 첨단의료기기 기술혁신센터)
  • Published : 2002.08.01
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Abstract

Localized hypoxia, due to the diminished $O_2$supply, is reported to cause necrosis of the arterial cell and to significantly decrease resistances to physiologic distending pressures. In the present study, in order to understand the mechanism of localized hypoxia which might result in the rupture of the aneurysm. $O_2$ transport phenomena across intraluminal thrombus in axisymmetric aneurysms under steady laminar flow condition were numerically analyzed using the Fick's law and the analogy with the fluid-solid heat transfer. For computational models, varying the thickness of intraluminal thrombus, numerical results showed that for the axisymmetric aneurysm with intraluminal thrombus. $O_2$ concentration became minimal at the aneurysm wall. With increased thickness of the intraluminal thrombus in the aneurysm. regions of low $O_2$ concentration were widely distributed near the aneurysm wall, which resulted in the possibility of localized hypoxia. The present study verifis that intraluminal thrombus influences $O_2$ transport to the aneurysm wall. depending on its size and structure.

국부적 저산소증(localized hypoxia)은 산소공급의 저하로 인하여 조직세포를 파괴하고 관강압력에 대한 동맥류 벽의 저항을 현저하게 감소시킨다고 보고되고 있다. 본 연구에서는 동맥류 파열의 원인이 되는 저산소증의 기전을 이해하기 위하여 혈전의 두께에 따라 세 가지의 축대칭 동맥류 모델을 구성하여 동맥류 내 혈전을 통한 정상 층류유동 (steady laminar flow)에서의 산소전달현상(O$_2$transport phenomenon)을 유체-고체 열전달 현상과의 유사성을 이용하고 Fick의 법칙을 적용하여 해석하였다. 전산해석을 통해서 혈전이 형성된 혈관에서 산소농도는 혈관 벽에서 가장 낮게 나타났으며 혈전의 크기가 증가할수록 저산소농도(low $O_2$concentration) 영역이 혈관 벽 가까이 넓게 분포되어 저산소증의 가능성이 증가됨을 알 수 있었다 본 연구를 통해서 동맥류 내의 혈전은 구조와 크기에 따라 산소의 흐름에 주요한 영향을 미침을 확인할 수 있었다.

Keywords

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