Journal of Microbiology and Biotechnology

  • 제12권4호
  • /
  • Pages.679-682
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  • 2002
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Inhibition of Aflatoxin $B_1$ Biosynthesis by Piperlongumine Isolated from Piper longum L.

  • Lee, Sung-Eun (Department of Agricultural chemistry, Kyungpook National University) ;
  • Mahoney, Noreen-E. (Plant Mycotoxin Research Unit, Western Regional Research Center, U.S. Department of Agriculture, Agricultural Research Service) ;
  • Campbell Bruce-C. (Plant Mycotoxin Research Unit, Western Regional Research Center, U.S. Department of Agriculture, Agricultural Research Service)
  • 발행 : 2002.08.01
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초록

The alkaloids, piperlongumine, piperine, pipernonaline, and piperoctadecalidine, isolated from Piper longum L., were found to inhibit the biosynthesis of aflatoxin $B_1$ (AF$B_1$) in Aspergillus flavus WRRC 3-90-42-12. Piperlongumine was the most active among the compounds tested, with a 96% inhibition of AF$B_1$biosynthesis at 0.2% (w/v) supplement in a potato dextrose agar (PDA) medium. The three other piperidine alkaloids, pipeline, pipernonaline, and piperoctadecalidine, also inhibited the biosynthesis of AF$B_1$. Of these three alkaloids, piperoctadecalidine exhibited a potent inhibitory activity with a 100% inhibition of AF$B_1$ production at 0.7% (w/v) supplement in a PDA medium. Therefore, piperlongumine and piperoctadecalidine could be used as antiaflatoxigenic agents in agricultural industries. To determine the antiaflatoxigenic mode of action of piperlongumine, further studies are needed.

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