한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition)

  • 제31권4호
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  • Pages.664-671
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  • 2002
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  • 1226-3311(pISSN)
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  • 2288-5978(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
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단식중인 흰쥐에서 지방섭취가 생존 대사에 미치는 영향

The Effects of Dietary Fat on Survival Metabolism of Fasting Rat

  • Seo, Yu-Seung (Dept. of Internal Medicine, Eul Ji General Hospital) ;
  • Sheo, Hwa-Jung (Dept. of Food and Nutrition, Chosun University)
  • 발행 : 2002.08.01
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초록

완전 단식군의 흰쥐(FO)와 단식중에 소기름(FT), 옥수수기름(FC), 들깨기름(FP)만을 각각 투여하고 비교하니 FO군은 대부분 6일까지 생존하고 FT, FC, FP군은 대부분 16일까지 생존하였다. 폐사 직전의 모든 흰쥐 체중은 -24.5~-25%로 감소되었다. 단식중 유지 섭취는 다소 생명을 연장하나 식이 유지 종류에 따른 생존기간과 체중 변화에 미치는 영향에는 괄목할 차이가 없었다. 간장과 신장 무게 변화도 체중변화와 유사한 양상을 보였다. FO군의 혈중 총 cholesterol 농도, 중성지방 농도, 혈당은 대폭 감소되고 GPT 활성값과 BUN 농도는 상당 수준으로 증가되었다. FC군과 FP군에서 유지의 n-6/n-3비율 혹은 불포화도 특성 차이가 총 cholesterol농도, 중성지방농도, 혈당농도, BUN농도, 단식 초기의 GPT활성도에 영향을 주지 못했다. 그러나 기아사 직전의 FP군에서 GPT활성도가 FT, FC군보다 높았다. 본 연구에서 결론은 기아 상태의 흰쥐에 유지 단독섭취는 유지 종류에 관계없이 생존일수를 다소 비슷하게 연장하였고 n-6/n-3비율, 불포화도 특성차이가 전반적으로 단식중의 대사에 미치는 영향에서 별다른 차이가 없었음을 알 수 있었다.

To investigate the effects of different type of dietary fat on survival metabolism of fasting rats, one group rats (FO) were fasted, another one group rats (BM) were fed normal diet and the others were fed only one of the following fat diets: beef tallow (FT), corn oil (FC), and perilla oil (FP) of 11.4g/kg respectively. Most FO group rats survived for 6 days and large part of the only-fat-diet groups rats survived for 16 days. Body weights of all rats in fasting and only-fat-groups, measured just one day prior to death owing to fasting or caloric malnutrition, decreased by 24.5%~25% only-fat to fasting rat somewhat extended the survival time but the specific properties of dietary fat types had no remarkably differential effect on survival time and body weight gain rate. The features of liver and kidney weight gain rate of all rats in fasting and only-fat-diet groups were similar to those of body weight gain rate. In FO groups blood levels of total-cholesterol, triglyceride, and glucose markedly reduced whereas GPT activities and BUN levels considerably increased as compared to BM group. However the types of dietary fat perse did not affect blood total cholesterol, triglyceride, glucose, BUN levels, and GPT activities in early stage of fasting in FC and FP group. GPT activities in rats of FP group just prior to death of starvation seemed to be affected by the dietary fat types. The results showed that only-fat-feeding to fasting rats somewhat extended survival time but the types of dietary fat had no remarkably differential effect on survival time and metabolism of fasting rats.

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