Environmental Mutagens and Carcinogens (한국환경성돌연변이발암원학회지)
- Volume 22 Issue 2
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- Pages.106-111
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- 2002
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- 1225-6307(pISSN)
Genotoxicity Studies of the Complex of Acriflavine and Guanosine
Acriflavine과 Guanosine 복합체(AG60)의 유전독성시험
Abstract
AG6O, the complex of acriflavine and guanosine, has been shown to possess the synergistic antitumorigenic activity in the previous paper (J. Pharm. Pharmacol. 1997, 49:216). In this study, we have investigated the genotoxic properties of AG60 using in vitro and in vivo system such as Ames bacterial reversion test, chromosomal aberration assay and micronucleus assay. In Ames reverse mutation test, AG60 treatment at the dose range up to 250
Keywords
- Acriflavine;
- guanosine;
- anti-tumorigenic agent;
- reverse mutation test;
- chromosome aberration test;
- micronucleus test