Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Inhibition of THIP on Morphine-Induced Hyperactivity, Reverse Tolerance and Postsynaptic Dopamine Receptor Supersensitivity

  • Oh, Ki-Wan (Department of Pharmacy, College of Pharmacy, Chungbuk National University) ;
  • Yoon, In-Seup (Department of Pharmacy, College of Pharmacy, Chungbuk National University) ;
  • Shin, Im-Chul (Department of Pharmacy, College of Pharmacy, Chungbuk National University) ;
  • Hong, Jin-Tae (Department of Pharmacy, College of Pharmacy, Chungbuk National University) ;
  • Lee, Myung-Koo (Department of Pharmacy, College of Pharmacy, Chungbuk National University)
  • Published : 2002.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study was performed to investigate the effect of tetrahydroisoxazolopyridine (THIP), a $GABA_A$ agonist, on the morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity in mice. A single administration of morphine induced hyperactivity in mice. However, the morphine-induced hyperactivity was inhibited dose-dependently by the administration of THIP (0.2, 0.4 and 0.8 mg/kg, i.p.). In contrast, daily administration of morphine resulted in a reverse tolerance to the hyperactivity caused by morphine (10 mg/kg ,s.c.). THIP inhibited the development of reverse tolerance in the mice that had received the repeated same morphine (10 mg/kg s.c.) doses. The postsynaptic dopamine receptor supersensitivity, which was evidenced by the enhanced ambulatory activity its after the administration of apomorphine (2 mg/kg s.c.), also developed in the reverse tolerant mice. THIP also inhibited the development of the postsynaptic dopamine receptor supersensitivity indulged by the chronic morphine administration. These results suggest that the hyperactivity, reverse toterance and postsynaptic dopamine receptor supersensitivity induced by morphine can be inhibited activating the $GABA_A$ receptors.

Keywords

References

  1. Allen, R. M. and Young, S. J., Phencyclidine-induced psychosis. Am. J. Psychiatry, 135, 1081-1084 (1978)
  2. Babbini, M. and Davis, W. M., Time-dose relationships for locomotor activity effects of morphine after acute or repeated treatment. Br. J. Pharmacol., 46, 213-224 (1972) https://doi.org/10.1111/j.1476-5381.1972.tb06866.x
  3. Bhargava, H. N., Cyclo (Leu-Gly) inhibits the development of morphine induced analgesic tolerance and dopamine receptor supersensitivity in rat. Life Sci., 27, 117-123 (1980)
  4. Dewey, S. L., Smith, G. S., Logan, J., Brodie, J. D., Yu, D. W., Ferrieri, R. A, King, P. T., MacGregor, R. R., Martin, T. P., and Wolf, A. P., GABAergic inhibition of endogenous dopamine release measured in vivo with $^{11}C$-raclopride and position emission tomography. J. Neurosci., 12, 3773-3780 (1992)
  5. Di Chiara, G. and Imperato, A., Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats. J. Pharmacol. Exp. Ther., 185, 1067-1080 (1988)
  6. Eidelberg., E. and Erspamer, R, Dopaminergic mechanisms of opiate actions in brain. J. Pharmacol. Exp. Ther., 192, 50-57 (1975)
  7. Finlay, J. M., Damsma, G., and Fibiger, H. C., Benzodiazepine-induced decreases inextracellular concentrations of dopamine in the nucleus accumbens after acute and repeated administration. Psychopharmacology, 106, 202-208 (1992) https://doi.org/10.1007/BF02801973
  8. Giorgetti, M., Javaid, J. I., Davis, J. M., Costa, E., Guidotti, A, Appel, S. B., and Brodie, M. S., Irridazenil, a positive allosteric GABA$_A$ receptor modulator, inhibits he effects of cocaine on locomotor activity and extracellular copamine in the nucleus accumbens shell without tolerance liability. J. Pharmacol. Exp. Ther., 287, 58-66 (1998)
  9. Gong, W., Neill, D. B., and Justice, D. B. J., GABAergic modulation of ventral pallidal dopamine release studied by in vivo microdialysis in the freely moving rat. Synapse, 29, 406-412 (1998) https://doi.org/10.1002/(SICI)1098-2396(199808)29:4<406::AID-SYN12>3.0.CO;2-O
  10. John, R. M. and Takemori, A. E., Chronically administered morphine increases dopamine receptor sensitivity in mice. Eur. J. Pharmacol., 121, 221-229 (1986) https://doi.org/10.1016/0014-2999(86)90493-0
  11. Kilbey, M. M. and Ellinwood, E. H., Reverse tolerance to stimulants-induced abnormal behavior. Life Sci., 20, 1063-1076 (1977) https://doi.org/10.1016/0024-3205(77)90294-6
  12. Kim, H. S., Kang, J. G., and Oh, K. W., Inhibition by ginseng total saponin of the development of morphine reverse tolerance and dopamine receptor supersensitivity in mice. Gen. Pharmacol., 26, 1071-1076 (1995) https://doi.org/10.1016/0306-3623(94)00267-Q
  13. Kim, H. S., Lim, H. K., and Park, W. K., Antinarcotic effects of the velvet antler water extract on morphine in mice. J. Ethnopharmacol., 66, 41-49 (1999) https://doi.org/10.1016/S0378-8741(98)00193-7
  14. Kuribara, H. and Tadokoro, S., Reverse tolerance to ambulationincreasing effects of MAP and MOR in 6 mouse strains, Jpn. J. Pharmacol., 49,197-203 (1989) https://doi.org/10.1254/jjp.49.197
  15. Kuschinsky, K. and Hornykiewicz, O., Effects of morphine on striatal dopamine metabolism: possible mechanism of its opposite effect on locomotor activity in rats and mice. Eur. J. Pharmacol., 26,41-50 (1974) https://doi.org/10.1016/0014-2999(74)90072-7
  16. Merrinne, E., Kankaanpaa, A., Lillsunde, P., and Seppala, T.: The effects of diazepam and zolpidem on cocaine- and amphetamine-induced place preference. Pharmacol. Biocbem. Behav., 62, 159-164 (1999) https://doi.org/10.1016/S0091-3057(98)00139-7
  17. Puri, S. K. and Lal, H., Effect of dopaminergic stimulation or blockade on morphine-withdrawal aggression. Psychopharmacology, 32, 113-120 (1973) https://doi.org/10.1007/BF00428682
  18. Rethy, C. R., Smith, C. B., and Villarreal, J. E, Effects of narcotic analgesics upon the locomotor activity and brair catecholamine content of the mouse. J. Pharmacol. Exp. Ther., 176 (2), 472-479 (1971)
  19. Ritzmann, R. F., Bhargava, H. N., and Flexner, L. B. Blockade of narcotic-induced dopamine receptor supersensitivity by cyclo (Leu-Gly). Proc. Natl. Acad. Sci. USA, 76, 5997-5998 (1976) https://doi.org/10.1073/pnas.76.11.5997
  20. Ritzmann, R. F., Lee, J. M., and Fielcs, J. Z.: Peptide inhibitions of morphine-induced dopaminergic supersensitivity. Life Sci., 31, 2287-2290 (1972) https://doi.org/10.1016/0024-3205(82)90139-4
  21. Roberts, D. C., Andrews, M. M., and Vickers, G. J., Baclofen attenuates the reinforcing effects of cocaine in rats. Neuro-psychopharmacology, 15, 417-423 (1996) https://doi.org/10.1016/0893-133X(96)00002-4
  22. Robinson, T. and Becker, J., Enduring changes in brain and behavior produced by chronic amphetamine administration a review and evaluation of animal models of amphetamine psychosis. Brain Res. Rev., 11, 157-198 (1986) https://doi.org/10.1016/0165-0173(86)90002-0
  23. Smolders, I., De Klippel, N., Sarre, S., Ebinger, G., and Michotle, Y.: Tonic GABA-ergic modulation of striatal dopamine release studied by in vivo microdialysis in the freely moving rat. Eur. J. Pharmacol. 284, 83-91 (1995) https://doi.org/10.1016/0014-2999(95)00369-V
  24. Spanagel, R., Herz, A., and Shippenberg, T. S, The effects of opioid peptides on dopamine release in the nucleus accumbens. An in vivo microdialysis study. J. Neurochem., 55, 1734-1740 (1990) https://doi.org/10.1111/j.1471-4159.1990.tb04963.x
  25. Suzuki, T., Tsuda, M., Funada, M., and Misawa, M., Blockade of morphine-induced place preference by diazepam in mice. Eur. J. Pharmacol., 280, 327-330 (1995) https://doi.org/10.1016/0014-2999(95)00249-K
  26. Tsuji, M., Nagawa, Y., Ishibashi, Y., Yoshii, T., Takashima, T., Shimada, M., and Suzuki, T., Activation of ventral tegmental GABAB receptors inhibits morphine-induced place preference in rats. Eur. J. Pharmacol., 313, 169-73 (1996) https://doi.org/10.1016/0014-2999(96)00642-5
  27. Woo, S. H. and Kim, H. S., Inhibition of baclofen on morphine-induced hyperactivity, reverse tolerance and postrynaptic dopamine receptor supersensitivity. Pharmacol. Res., 43, 335-40 (2001) https://doi.org/10.1006/phrs.2000.0789
  28. Wood, P. L. and Altar, C. A., Dopamine release in vivo from nigrostriatal mesolimbic and mesocortical neurons utility of 3-methoxytryramine measurements. Pharmacol. Rev., 40, 163-187 (1988)
  29. Xi, Z. X. and Stein, E.A., Baclofen inhibits heroin self-administration behavior and mesolimbic dopamine release. J. Pharmacol. Exp. Ther., 290, 1369-74 (1999)
  30. Yoon, I. S., Kim, H. S., Hong, J. T., Lee, M. K., and Oh, K. W. Inhibition of muscimol on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity. Pharmacology, (2002 in press)