Antimicrobial Constituents of Foeniculum vuigare

  • Kim, Chang-Min (College of Pharmacy, Kangwon National University) ;
  • Kwon, Yong-Soo (College of Pharmacy, Kangwon National University) ;
  • Choi, Won-Gyu (College of Pharmacy, Kangwon National University) ;
  • Kim, Won-Jun (College of Pharmacy, Kangwon National University) ;
  • Kim, Woo-Kyung (College of Pharmacy, Kangwon National University) ;
  • Kim, Myong-Jo (College of Agricultural and Life Science, Kangwon National University) ;
  • Kang, Won-Hee (College of Agricultural and Life Science, Kangwon National University)
  • Published : 2002.04.01

Abstract

A phenyl propanoid derivative, dillapionall(7) was found to be a antimicrobial principle of the stems of Foeniculum vuigare (Umbelliferae) with MIC values of 125, 250 and 125/ against Bacillus subtilis, Aspergillus niger and Cladosprium cladosporioides respectively. A coumarin derivative, scopoletin(2) was also isolated as marginally antimicrobial agent along with inactive compounds, dillapiol(3), bergapten(4), imperatorin(5) and psolaren(6) from this plant. The isolates 1-6 were not active against the Escherichia coli.

Keywords

References

  1. Ceska, O., Chaudgary, S. K., Warrington, P. J., Ashwood-Smith, M. J., Photoactive furocoumarins in fruits of some umbellifers. Phytochemistry, 26,165-169 (1986) https://doi.org/10.1016/S0031-9422(00)81503-4
  2. Eigamal, M. H. A., Elewa, N. H., Elkhrisy, E. A. M. and Duddeck, H., $^{13}C$ NMR chemical shift and carbon-proton coupling constants of some furocoumrins and furochromones. Phytochemistry, 18, 139-143 (1979) https://doi.org/10.1016/S0031-9422(00)90932-4
  3. Harkar, S., Razden, T. K., Waight, E. S., Steroids, chromone and coumrins from Angelica officinalis. Phytochemistry, 23, 419-426 (1984) https://doi.org/10.1016/S0031-9422(00)80344-1
  4. Kim, C. M., Sin, M. K., Lee, K. S. and Ahn, D. K., The dictionary of Chinese medicines, Jungdam press, Seoul, pp. 6597-6604, 1997
  5. Lee, K. H. and Soine, T.O., Coumain : Spectral studies on some linear furocoumarins, J. Pharm. Sci., 58, 681-683 (1969) https://doi.org/10.1002/jps.2600580606
  6. Ono, M., Ito, Y, Ishikawa, T, Kitajima, J., Tanaka, Y, Niiho, Y. and Nohara, T, Five new monoterpene glycosides and other compounds from Foeniculi Fructus (Fruit of Foeniculum vulgare Miller). Chem. Pharm. Bull., 44, 337-342 (1996) https://doi.org/10.1248/cpb.44.337
  7. Ono, M., Ito, Y., Kinjo, J., Yahara, S., Nohara, T. and Niiho, Y., Four new glycosides of stilbene trimer from Foeniculi Fructus (Fruit of Foeniculum vulgare Miller). Chem. Pharm. Bull., 43, 868-871 (1995) https://doi.org/10.1248/cpb.43.868
  8. Orjala, J., Erdelmeier, C. A. J., Wright, A. D., Rali, T. and Sticher, O., Five new prenylated p-hydroxybenzoic acid derivatives with antimicrobial and molluscicidal activity from Piper aduncum leaves. Planta Med., 59, 546-551 (1993) https://doi.org/10.1055/s-2006-959758
  9. Steck W. and Mazurek, M., Identification of natural coumarins by nmr spectroscopy. Lloydia, 35, 418-439 (1972)
  10. Tomar, S. S. and Mukerjee, Dillapional, a new constituent of Anethum sowa Roxb. Indian J. Chem., 20B, 723-724 (1981)