Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Structure Determination of a New Lupane-type Triterpene, Tiarellic Acid, Isolated from Tiarella polyphylla

  • Lee, Hyeong-Kyu (Immunomodulator Research Laboratory Korea Research Institute of Bioscience & Biotechnology) ;
  • Park, Si-Hyung (Department of Medicinal Plant Resources, Mokpo National University) ;
  • Oh, Sei-Ryang (Immunomodulator Research Laboratory Korea Research Institute of Bioscience & Biotechnology) ;
  • Ahn, Kyung-Seop (Immunomodulator Research Laboratory Korea Research Institute of Bioscience & Biotechnology) ;
  • Kim, Jae-Gil (Institute of Natural Drug Resources)
  • Published : 2002.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

A new 27-carboxylic lupane-type triterpene, tiarellic acid (1), was isolated from Tiarella polyphylla together with corosolic acid (2) and tormentic acid (3). Tiarellic acid was characterized as 3,23-dihydroxy-20(29)-lupen-27-oic acid and its NMR data were unambiguously assigned using 2-D NMR techniques.

Keywords

References

  1. Lee, Y. N. in Flora of Korea, Kyo-Hak Publishing Co., Seoul, 1996
  2. Hotta, M., Ogata, K., Nitta, A., Hosikawa, K., Yanagi, M., and Yamazaki, K. in Useful Plants of the World, Heibonsha LTD Publishers, Tokyo, 1989
  3. Mahato, S. B., Sarkar, S. K., and Poddar, G, Triterpenoid saponins, Phytochemistry 27, 3037-3067 (1988) https://doi.org/10.1016/0031-9422(88)80001-3
  4. Misra, T. N., Singh, R. S. and Upadhyay, J. A natural triterpene acid from Hyptis suaveolens, Phytochemistry 22, 2557-2558 (1983) https://doi.org/10.1016/0031-9422(83)80163-0
  5. Nair, S. P. and Rao, J. M., Gouanic acid from the leaves of Gouania microcarpa, Phytochemistry 33, 711-712 (1993) https://doi.org/10.1016/0031-9422(93)85479-B
  6. Yang, M. H., Blunden, G. ONeill, M. J., and Lewis, J. A. Tormentic acid and 2-hydroxyursolic acid from Amebia euchrome, Planta Med. 58, 227 (1992) https://doi.org/10.1055/s-2006-961439