Archives of Pharmacal Research

  • 제25권1호
  • /
  • Pages.25-27
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  • 2002
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

The Crystal Structure of KR-27042, An Analgesic Capsaicinoid

  • Park, No-Sang (Korea Research Institute of Chemical Technology) ;
  • Kim, Yang-Bae (College of Pharmacy, Seoul National University) ;
  • Jeong, Eun-Ju (Institute of Science and Technology, Cheil Jedang Corporation) ;
  • Chung, Uoo-Tae (College of Pharmacy, Chungbuk National University) ;
  • Park, Il-Yeong (College of Pharmacy, Chungbuk National University)
  • 발행 : 2002.02.01
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초록

The crystal structure of KR-21042, N-(3-Phenylpropyl )-4-hydroxy-3-methoxyphenylacetamide, was determined by single crystal X-ray diffraction analysis. The compound was recrystallized from a mixture of ethylacetate and n-hexane in monoclinic, space group $P2_1/c$, with a = 16.622(1), b = 6.215(1), c = 15.802(1) ${\AA},{\;}{\beta}=104.97(1)$, and Z = 4 The calculated density is $1.261{\;}g/cm^3$The structure was solved by the direct method and refined by full matrix least-squares procedure to the fecal R value of 0.068 for 2332 observed reflections.

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참고문헌

  1. Altomare, A., Cascarano, G., Giacovazzo, C. & Gualiardi, A (1993) Completion and refinement of crystal structures with SIR92, J. Appl. Cryst. 26, 343-350 https://doi.org/10.1107/S0021889892010331
  2. Choi, J. -K., Hong, M. -S., Park, N. -S., Lee, K.-S., Choi, J., Kim, H. -J., and Ha, D. -C. Synthesis of capsaicinoids: 3-Hydroxy4(2-aminoethoxy)phenylacetamides, Kor. J. Med. Chem., 3, 25-32. (1993)
  3. Dray, A, Novel Aspects Pain Manage, Sawynok, J., and Cowan, A. Ed., Willey-Liss, New York, pp.117-134 (1999)
  4. James, lain F., Garcia, R., Liapi, A., and Wood, J.N., Malecualr Basis of Pain Induction, Wood J. N. Ed. Wiley-Liss, New York, pp. 175-191 (2000)
  5. Johnson, C. K., ORTEPII: A FORTRAN thermal-ellipsoid plot program for crystal structure illustrations (ORNL-5138), Oak Ridge National Laboratory, Tennessee, 1976
  6. Kim, Y. B., Kim, J. A., and Park, I. Y, The crystal structure of acemetacin monohydrate ($C_{21}H_{18}NO_{6}CIH_{2}O$), a non-steroidal antiinflammatory agent. Arch. Pharm. Res., 16(2), 134-139 (1993) https://doi.org/10.1007/BF03036861
  7. Kim, Y. B., Park, I. Y., and Lah, W. R., The crystal structure of naproxen sodium, ($C_{14}H_{13}O_{3}Na$), a non-steroidal antiinflammatory agent, Arch. Pharm. Res., 13(2), 166-173 (1990) https://doi.org/10.1007/BF02857795
  8. Mackay, S., Edwards, C., Henderson, A., Gilmore, C., Stewart, N., Shankland, K. & Donald, A. maXus 1.1, A computer program for the solution and refinement of crystal structures from X-ray diffraction data, University of Glasgow, Scotland, Nonius, The Netherlands, and MacScience, Japan. (1997)
  9. Park, N. -S., Ha, D. -C., Choi, J. -K., Kim, H. -S., Lim, H. -J., and Lee, B.-Y., N-Aralkylated 4-(2-aminoethoxy)phenylacetamide derivatives as potent analgesic and antiinflammatory agents, Kor. J. Med. Chem., 1, 36-43. (1991a)
  10. Park, N. -S., Ha, D. -C., Kim, H. -S., and Choi, J.-K., Phenylacetamide derivatives as analgesic agents, Kor. J. Med. Chem., 1, 2-7. (1991b)
  11. Park, N.-S., Kim, Y.B., Jeong, E.J., Chung, U.T., and Park, I.Y. Crystal structure of capsaicin, in preparation. (2002a)
  12. Park, N.-S., Kim, Y.B., Jeong, E.J., Chung, U.T., and Park, I.Y Crystal structure of KR-25018, in preparation. (2002b)
  13. Park, N. -S., Lee, J. -C., Park, I. Y., and Kim, Y.B.; KR-25003, A potent analgesic capsaicinoid, Acta Crystallogr., C51, 927-929 (1995)
  14. Suzuki, T. and Iwai, K. The alkaloids. Vol. XXIII., edited by A. Brossi, Academic Press, Orlando, pp. 227-299, USA (1984)