The Plant Pathology Journal

The Korean Society of Plant Pathology (한국식물병리학회)
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Verlamelin, an Antifungal Compound Produced by a Mycoparasite, Acremonium strictum

  • Kim, Jin-Cheol (Bioorganic Science Division, Korea Research Institute of Chemical Technology) ;
  • Park, Gyung-Ja (Bioorganic Science Division, Korea Research Institute of Chemical Technology) ;
  • Kim, Hyun-Ju (Bioorganic Science Division, Korea Research Institute of Chemical Technology) ;
  • Kim, Heung-Tae (Bioorganic Science Division, Korea Research Institute of Chemical Technology) ;
  • Ahn, Jong-Woong (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Cho, Kwang-Yun (Bioorganic Science Division, Korea Research Institute of Chemical Technology)
  • Published : 2002.04.01
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Abstract

A strain of Acremonium strictum, the mycoparasite of Botrytis cinerea, showed strong antifungal activities both in vitro and in vivo against several phytopathogenic fungi. An antifungal substance was purified from the liquid cultures of A. strictum and identified as verlamelin by instrumental analyses. Verlamelin exhibited in vitro antifungal activity against some phytopathogenic fungi such as Magnaporthe grisea, Bipolaris maydis, and Botrytis cinerea, while it was net active against all the bacteria tested. In viva, verlamelin exhibited strong protective and curative activities, particularly against barley powdery mildew. At 100 μg/ml, it inhibited the development of barley powdery mildew with control values of more than 90% in 7-day protective and 2-day curative applications. This is the first report on the production of verlamelin by Acremonium species.

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References

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