The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Effects of Strychni Ignatii Semen on Toxicity Levels and Gastrointestinal Tract

보두(寶豆)의 수치법(修治法)에 따른 독성(毒性) 및 소화기계(消化器系)에 미치는 영향(影響)

  • Kim, Jin-Sung (Department of 3rd Internal Medicine, Oriental Medicine, Kyung Hee University) ;
  • Yoon, Sang-Hyub (Department of 3rd Internal Medicine, Oriental Medicine, Kyung Hee University) ;
  • Ryu, Bong-Ha (Department of 3rd Internal Medicine, Oriental Medicine, Kyung Hee University) ;
  • Ryu, Ki-Won (Department of 3rd Internal Medicine, Oriental Medicine, Kyung Hee University) ;
  • Cho, Yu-Kyung (Department of 3rd Internal Medicine, Oriental Medicine, Kyung Hee University)
  • 김진성 (경희대학교 한의과대학 비계내과학교실) ;
  • 윤상협 (경희대학교 한의과대학 비계내과학교실) ;
  • 류봉하 (경희대학교 한의과대학 비계내과학교실) ;
  • 류기원 (경희대학교 한의과대학 비계내과학교실) ;
  • 조유경 (경희대학교 한의과대학 비계내과학교실)
  • Published : 2002.03.30
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Abstract

Objective : These experiments were designed to investigate the effects of Strychni Ignatii Semen on the gastrointestinal system and declining of toxicity. About experiments of acute toxicity, I investigated the quantity of Strychni $(C_{21}H_{22}N_2O_2)\;and\;LD_{50}$. In order to study the effects on gastrointestinal tract, I investigated the changes of gastric juice, discharging level of pepsin, inhibiting effects of ulceration, and transporting of intestine. Methods : Sample I : No making Strychni Ignatii Semen Sample II : Depositing for three days in water and then dry it. Sample III : Depositing for one hour in sesame oil and bum it. The results were as follows : 1. The average values of Strychnine decreased in Sample III. 2. The levels of $LD_{50}$ increased in Sample Ⅲ by about 70%. 3. In Sample III, inhibiting effects of ulceration and discharging level of pepsin were great. 4. In the level of gastric juice decreased in Sample I.II.III. 5. The transporting ability of large intestine elevated in Sample I.II.III. According to the results, making Strychni Ignatii Semen, especially Sample 3, toxicity decreased and has good effects on the gastrointestinal system.

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References

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