The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Predictive Value of the Methylenetetrahydrofolate Reductase Gene Mutation for Multiple Infarction and Small Artery Infarction

Multiple Infarction과 Small Artery Infarction의 독립적 위험인자로서의 Methylenetetrahydrofolate Reductase Gene Mutation

  • Jung, Jung-Uk (Department of Internal Oriental Medicine, College of Medicine, Pochon Jung Moon University) ;
  • Park, Jung-Mi (Department of Internal Oriental Medicine, College of Medicine, Pochon Jung Moon University) ;
  • Choi, Byung-Ok (Department of Neurology, College of Medicine, Pochon Jung-Moon University) ;
  • Kim, Nam-Keun (Institute for Clinical Research, College of Medicine, Pochon Jung-Moon University) ;
  • Oh, Do-Yeun (Institute for Clinical Research, College of Medicine, Pochon Jung-Moon University) ;
  • Jung, Woo-Sang (Department of Internal Oriental Medicine, College of Medicine, Pochon Jung Moon University)
  • 정정욱 (포천중문의과대학교 분당차한방병원 한의학교실 내과) ;
  • 박정미 (포천중문의과대학교 분당차한방병원 한의학교실 내과) ;
  • 최병옥 (포천중문의과대학교 분당차병원 신경과학교실) ;
  • 김남근 (포천중문의과대학교 분당차병원 임상의학연구소) ;
  • 오도연 (포천중문의과대학교 분당차병원 임상의학연구소) ;
  • 정우상 (포천중문의과대학교 분당차한방병원 한의학교실 내과)
  • Published : 2002.03.30
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Abstract

Objective : Hyperhomocysteinemia has been proven to be an independent risk factor for stroke. The genetic mutation of methylenetetrahydrofolate reductase(MTHFR) elevates serum homocysteine level, but it still remains controversial whether the MTHFR gene mutation could be a predictor of ischemic stroke. Therefore, we studied if this genetic defect could cause ischemic stroke independently. Methods : We gathered ischemic stroke subjects and age, sex-matched controls. Age, gender, past medical history, smoking habit, serum homocysteine level, and the MTHFR genotype were recorded. General characteristics of ischemic stroke subjects were compared to the controls. We classified the stroke according to the related vessels(small and large artery infarction) and single lesion and multiple infraction. Relevant risk of the MTHFR genotype was evaluated in each stroke subtype with multiple logistic regression analysis. Results : When the controls were compared to the whole ischemic stroke, there was no specific difference except some medical histories. However, further analysis based on stroke subtypes showed important results. The small artery infarction group, multiple infraction group had significant odds ratio of the MTHFR TT genotype adjusted for age, gender, medical history and smoking habit. Conclusions : The MTHFR TT genotype is an independent risk factor for certain types of ischemic stroke, small artery infarction and multiple infarction.

Keywords

References

  1. Ann Rev Nutr v.12 Hyperhomocystinemia as a risk factor for occlusive vascular disease Kang, S.S.;Wong, P.W.K.;Malinow, M.R.
  2. J Am Cardiol v.27 Homocysteine and coronary atherosclerosis Mayer, E.L.;Jacobsen, D.W.;Robinson, K.
  3. Stroke v.29 Relation of plasma homocysteine to cerebral infarction and cerebral atherosclerosis Yoo, J.H.;Chung, C.S.;Kang, S.S.
  4. Nat Genet v.10 A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Frosst, P.;Blom, H.J.;Milos, R.;Goyette, P.;Sheppard, C.A.;Matthews, R.F.;Boers, G.J.H.(et al.)
  5. Arterioscler Thromb Vasc Biol v.18 Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese Morita, H.;Kurihara, H.;Tsubaki, S.;Sugiyama, T.;Hamada, C.;Kurihara, Y.(et al.)
  6. Stroke v.28 A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease Markus, H.S.;Ali, N.;Swaminathan, R.;Sankaralingam, A.;Molloy, J.;Powell, J.
  7. Stroke v.24 Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial TOAST. Trial of Org 10172 in Acute Stroke Treatment H.P. Jr.;Bendixen, B.H.;Kappelle, L.J.;Biller, J.;Love, B.B.;Gordon, D.L.;Marsh, E.E. 3rd.
  8. Clin Chem v.39 Homocysteine and other thiols in plasma and urine: automated determination and sample suitability Fiskerstrand, T.;Refsum, H.;Kralheim, G.;Ueland, P.M.
  9. Circulation v.88 Thermolabile defect of methylenetetrahydrofolate reductase in coronary artery disease Kang, S.S.;Passen, E.L.;Ruggie, N.;Wong, P.W.K.;Sora, H.
  10. Arterioscler Thromb Vasc Biol v.99 Genetic analysis of the thermolabile variant of 5,10-methylenetetrahydrofolate reductase as a risk factor for ischemic stroke Harmon, D.L.;Doyle, R.M.;Meleady, R.;Doyle, M.;Shiels, D.C.;Barry, R.(et al.)
  11. Arterioscler Thromb Vasc Biol v.20 Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia Yoo, J.H.;Choi, G.D.;Kang, S.S.
  12. Am J Cardiol v.75 Homocysteine and coronary artery disease in French Canadian subjects: relation with vitamins B12, B6, pyridoxal phosphate, and folate Dalery, K.;Lussier-Cacan, S.;Selhub, J.;Davignon, J.;Latour, Y.;Genest, J. Jr(et al.)
  13. Circulation v.93 Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and homocysteine concentrations Jacques, P.F.;Bostom, A.G.;Williams, R.R.;Ellison, R.C.;Eckfeldt, J.H.;Rosenberg, I.H.(et al.)
  14. Proc. Narl. Acad. Sci. USA Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage Blount, B.C.;Mack, M.M.;Wehr, C.M.;MacGregor, J.T.;Hiatt, R.A.;Wang, G.(et al.)