Study on the Toxicity of Hangam-dan(HAD) in Mice

항암단의 안전성(安全性)에 관(關)한 실험적(實驗的) 연구(硏究)

  • Kim, Hee-Cheol (Department of East-West Cancer, College of Oriental Medicine, Daejeon University) ;
  • Song, Ki-Cheol (Department of East-West Cancer, College of Oriental Medicine, Daejeon University) ;
  • Yoo, Hwa-Seung (Department of East-West Cancer, College of Oriental Medicine, Daejeon University) ;
  • Cho, Jung-Hyo (Department of East-West Cancer, College of Oriental Medicine, Daejeon University) ;
  • Lee, Yeon-Weol (Department of East-West Cancer, College of Oriental Medicine, Daejeon University) ;
  • Son, Chang-Kyu (Department of East-West Cancer, College of Oriental Medicine, Daejeon University) ;
  • Cho, Chong-Kwan (Department of East-West Cancer, College of Oriental Medicine, Daejeon University) ;
  • Lee, Yong-Gu (Department of Internal Medicine, Hye-Hwa Hospital, Daejeon University) ;
  • Choi, Byung-Lyul (Department of East-West Cancer, College of Oriental Medicine, Daejeon University)
  • 김희철 (대전대학교 한의과대학동서암센터) ;
  • 송기철 (대전대학교 한의과대학동서암센터) ;
  • 유화승 (대전대학교 한의과대학동서암센터) ;
  • 조정효 (대전대학교 한의과대학동서암센터) ;
  • 이연월 (대전대학교 한의과대학동서암센터) ;
  • 손창규 (대전대학교 한의과대학동서암센터) ;
  • 조종관 (대전대학교 한의과대학동서암센터) ;
  • 이용구 (대전대학교 부속혜화병원내과) ;
  • 최병렬 (대전대학교 한의과대학동서암센터)
  • Published : 2002.12.30

Abstract

This study was carried out to investigate the oral toxicity of HAD in mice. The results were summarized as follows: 1. HAD did not induced any toxicological effect in the body weight changes of mice. 2. HAD(2.5g/kg, 0.25g/kg) treated group were increased as compared with control group in the hematological values of mice. 3. ALT, AST, BUN, creatinine, CPK were not increased in HAD(2.5g/kg, 0.25g/kg) treated group as compared with control group in the serological values of mice. 4. Brain, Heart, Liver, Spleen, Kidney's weight were not increased in HAD(2.5g/kg, 0.25g/kg) treated group as compared with control group in the organ's weight of mice. 5. HAD(2.5g/kg, 0.25g/kg) treated group did not induced any toxicological effect in the gross findings in mice's any organs. 6. HAD(10g/kg , 5g/kg, 2.5g/kg, 1.25g/kg) treated group did not induced any toxicological effect in the histopathological findings in mice's any organs. 7. HAD(2.5g/ kg, 0.25g/ kg) treated group did not induced any toxicological effect in the histopathological findings in mice's any organs. From above results, HAD has not toxicological effects to mice.

Keywords

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