Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Effect of Water Extract of Ulmi pumilae Cortex on Gastric Ulcer in Rats

유백피(楡白皮) 물 추출물이 흰쥐의 위궤양(胃潰瘍)에 미치는 영향(影響)

  • Lim, Jong-Pil (Department of Oriental Pharmacy, Woosuk University) ;
  • Cui, Xun (Department of Oriental Pharmacy, Woosuk University)
  • 임종필 (우석대학교 한약학과) ;
  • 최훈 (우석대학교 한약학과)
  • Published : 2002.09.30
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Abstract

Ulmi pumilae Cortex(bark of Ulmus pumila L.), oriental medicine, has been used for the folk remedy of the gastric diseases. In order to investigate antiulcer activities, some experiments for Shay, aspirin-induced and indomethacin-induced gastric ulcers were conducted. The water extract of Ulmi pumilae Cortex(UX) was given intraperitoneally, and the groups of UX 500 and 1,000mg/kg significantly inhibited Shay, aspirin and indomethacin-induced ulcers in rats.

유백피 물 추출물의 위궤양치료 효과를 확인하기 위하여 여러 비율의 농도로 rat에 대한 투여량을 조절하면서 Shay, aspirin 및 Indomethacin으로 유도된 위궤양에 대하여 실험하였던 바 유백피의 물 추출물을 각기 500 및 1000mg/kg을 투여하였을 때 항궤양 효과가 유의성 있게 농도 의존적으로 증가하였으며 Shay궤양이나 aspirin유발 궤양보다도 indomethacin유발 궤양의 경우에 더욱 항궤양 효과가 좋았다.

Keywords

References

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