Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Screening of Inhibitory Activity of Medicinal Plants against Heparinase

수종 생약의 Heparinase 저해활성 검색

  • Ahn, Soon-Cheol (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Kim, Bo-Yeon (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Oh, Won-Keun (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Lee, Myung-Sun (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Bae, Eun-Young (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Kang, Dae-Wook (Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Ahn, Jong-Seog (Korea Research Institute of Bioscience and Biotechnology (KRIBB))
  • Published : 2002.06.30
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Abstract

The methanol extracts of 132 herbal medicines were screened for the inhibitory activity against heparinase enzyme from Flavobacterium heparinum. Eleven medicinal plants, Amomum xanthiodides, Agrimonia pilosa, Paeonia lactiflora, Rubia cordifolia, Sanguisorba officinalis, Torrega grandis, Morus alba, Gleditsia sinensis, Crataegus pinnatifida, Cornus officinalis, Paeonia japonica showed potent inhibition on heparinase activity. The active substituents of those herbal medicine could be extracted into butanol fraction and the inhibitory compounds of Morus alba are now isolating.

Keywords

References

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