Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Evaluation of DNA Strand-Scission Activity of the Korean Indigenous Plants

  • Choi, Hye-Young (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University) ;
  • Han, Ah-Reum (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University) ;
  • Mar, Woong-Chon (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Seo, Eun-Kyoung (Natural Products Chemistry Laboratory, College of Pharmacy, Ewha Womans University)
  • Published : 2002.12.01
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Abstract

The methanol extracts of 42 Korean indigenous plants were evaluated for the DNA strand-scission activity. As a result, the 17 extracts were found to be active in the criteria of $IC_{50}$}<$25\;{\mu}g/ml$. Among others, the MeOH extracts of Caesalpinia sappan and Mucuna birdwoodiana showed the most potent DNA strand-scission activity with $IC_{50}$ values of 5.9 and $4.9\;{\mu}g/ml$, respectively. Therefore, the partition and fractionation for C. sappan were performed and tested in the DNA strand-scission assay system for further bioassay-guided fractionation.

Keywords

References

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