The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Effect of Kamihyunggyeyungyotang on Interleukin-8 & $TGF-{\beta}1$ in Middle Ear Effusion for Pediatric Recurrent Otitis Media with Effusion

소아(小兒) 재발성(再發性) 삼출성(渗出性) 중이염(中耳炎)에서 가미형개연교탕(加味荊芥蓮翹湯)이 중이강(中耳腔) 삼출액(渗出液) 내(內) IL-8과 $TGF-{\beta}1$에 미치는 영향(影響)

  • Kim, Hyun-Hee (Dept. of Pediatrics, College of Oriental Medicine, Wonkwang University) ;
  • Park, Eun-Jeung (Dept. of Pediatrics, College of Oriental Medicine, Wonkwang University) ;
  • Joo, Jong-Cheon (Oriental Medical Hospital of Wonkwang University in Gwangju)
  • 김현희 (원광대학교 한의과대학 소아과학교실) ;
  • 박은정 (원광대학교 한의과대학 소아과학교실) ;
  • 주종천 (원광대학교 광주한방병원)
  • Published : 2002.12.31
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Abstract

The author measured IL-8 and $TGF-{\beta}1$ levels of 84 ears - 48 ears of them had treated by antibiotics, 36 of them by Kamihyunggyeyungyotang(KHY) - of pediatric recurrent otitis media with effusion using ELISA assay, and compared them. The results were obtained as follows. 1. The level of IL-8 in KHY group was significantly lower than that in antibiotics group(p<0.05). 2. The level of $TGF-{\beta}1$ in KHY group was lower than that in antibiotics group. According to above results, KHY is considered to be used for treating recurrent otitis media with effusion by controlling the production of interleukin-8 and transforming $growthfactor-{\beta}1$.

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