보양성장탕(補陽成長湯)이 생쥐와 흰쥐의 성장(成長)에 미치는 영향(影響)

The effect of Boyangsengjang-Tang on the growth of mice and rats

This study was designed to observe the efficacy of Boyangsengjang-Tang(BST) on the growth of rats. The effects on growth, and the secretion of hormones in the serum was measure. Male BALA/C mice(weight 20-25g), and male ICR rats(weigh 120-150g), were each divided into 3 groups : Sample A, Sample B and a Control group. Each group consisted of 4 mice and 5 rats. Mice received $5{\mu}{\ell}$ BST, and rats received $50{\mu}{\ell}$ BST, daily. Sample A was administered with normal BST for 3 weeks. Sample B was was administered with 10 times the normal amount of BST for 3 weeks. Control group was administered with normal saline for 3 weeks. The body weight, body length, subcutaneous fat, length of femur, serum GH, serum IGFBP-3 and serum in TSH were measured at 1, 2, and 3 weeks. The results were as follows ; 1. The body weigh of the rats increased significantly in Sample A after 3 weeks when compared with control group. 2. The body length in rats increased significantly in Sample A when compared with control group. 3. The amount of subcutaneous fat in the mice increased significantly in Sample B after 1 week when compared with control group. The amount of subcutaneous fat in rats increased significantly in Sample A and Sample B after 3 weeks when compared with the control group. 4. The length of the femur in rats increased significantly in Sample in A and Sample B in 1, 2, and 3 weeks when compared with the control group. 5. The level of GH, IGFBP-3 and TSH in the serum was not statically different when compared with the control group. According to the above results, BST (which reinforces the Kidney's Yang and strengthens muscle and bone) increases body weight, body length, subcutaneous fat and the length of the femur when compaired with the control group. BST therefore seems to improve growth.