Advances in Traditional Medicine

  • 제2권1호
  • /
  • Pages.52-57
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  • 2002
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  • 2662-4052(pISSN)
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  • 2662-4060(eISSN)
경희대학교 융합한의과학연구소 (Kyung Hee Oriental Medicine Research Center)
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Antitumor evaluation and antimicrobial activity of geranyl phenyl ethers

  • Oh Hyun-Ju (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Korea Institute of Oriental Pharmacy) ;
  • Shin Ji-Hee (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Korea Institute of Oriental Pharmacy) ;
  • Chung Woo-Young (Department of Oral Anatomy, School of Dentistry, Wonkwang University) ;
  • Han Du-Seok (Department of Oral Anatomy, School of Dentistry, Wonkwang University) ;
  • Baek Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine and Korea Institute of Oriental Pharmacy)
  • 발행 : 2002.02.01
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초록

Geranyl phenyl ethers 1, 2, 3, 4 and 5, 5-fluorouracil 6 and adriamycin 7 as references were tested for their growth inhibitory effects against tumor cell lines and NIH 3T3 fibroblasts using two different assays, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and sulforhodamine B protein (SRB) assays. These results suggest that methyl-4-[{(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-methoxy benzoate 1 showed growth inhibition activity against tumor cell lines. The maximum activity exhibited by methyl-4-[{(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-hydroxybenzoate 3 against Staphylococcus epidermidis (MIC, $1,000{\mu}g/ml$).

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