Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Association Study of Dopamine Transporter(DAT1) G2319A Genetic Polymorphism in Alcohol Dependence

알코올의존 환자의 도파민 수송체(DAT1)G2319A의 유전자 다형성 연합연구

  • Yang, Byung-Hwan (Department of Neuropsychiatry, College of Medicine & The Mental Health Research Institute, Hanyang University) ;
  • Lee, Mi-Gyung (Department of Neuropsychiatry, College of Medicine & The Mental Health Research Institute, Hanyang University) ;
  • Choi, Ju-Yoen (Department of Neuropsychiatry, College of Medicine & The Mental Health Research Institute, Hanyang University) ;
  • Oh, Dong-Yul (Seoul National Mental Hospital) ;
  • Kim, Gil-Sook (Seoul National Mental Hospital) ;
  • Kim, Hyung-Tae (Department of Biochemistry, Molecular Biology, College of Science-technelogy, Hanyang University) ;
  • Chai, Young-Gyu (Department of Biochemistry, Molecular Biology, College of Science-technelogy, Hanyang University)
  • 양병환 (한양대학교 의과대학 신경정신과학교실 및 정신건강연구소) ;
  • 이미경 (한양대학교 의과대학 신경정신과학교실 및 정신건강연구소) ;
  • 최주연 (한양대학교 의과대학 신경정신과학교실 및 정신건강연구소) ;
  • 김길숙 (국립서울 정신병원) ;
  • 오동열 (국립서울 정신병원) ;
  • 김형태 (한양대학교 과학기술대학 생화학.분자생물학교실) ;
  • 채영규 (한양대학교 과학기술대학 생화학.분자생물학교실)
  • Published : 2001.12.31
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Abstract

Objective : Dopamine transporter is member of family of Na/Cl dependent neurotransmitter transporter, 12 transmembrane domain, that has high substrate specificity, affinity. It is related with dopamine reuptake in presynaptic vesicle. DAT has a VNTR in its 3'-untranslated region(UTR). 3'-UTR VNTR polymorphism is related with modification of dopamine transmission. The association between with VNTR polymorphism and neuropsychiatric disorders such as alcohol dependence, and low activity ALDH has been studied, but their relationship is unclear. We study about association of 3'-UTR VNTR of DAT gene and G2319A and alcohol dependence. Method : Group of Korean subjects were studied with alcohol dependence(n=49 male) compared to mentally healthy controls(n=53 male). The peripheral blood sample was acquired, and Polymerase Chain Reaction(PCR) amplification, MspI procedure was done. Result : There was a significant difference between alcohol dependence group and normal control(genotype frequency p<0.05, allele frequency p<0.05) Allele A frequency and genotype(GG, GA) frequency was a significant difference between alcohol dependence group and normal control(p<0.05). Conclusion : Our study showed that genetic polymorphism of DAT1 G2319A had relation with alcohol dependence.

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