Tuberculosis and Respiratory Diseases
- 제51권4호
- /
- Pages.354-363
- /
- 2001
- /
- 1738-3536(pISSN)
- /
- 2005-6184(eISSN)
폐를 침범한 피부근염/다발성근염의 임상적 양상
Clinical Features of Dermatomyositis/Polymyositis(DM/PM) with Lung Involvement
- 박근민 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 최창민 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 엄상원 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 황용일 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 임채준 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 이재호 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 유철규 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 이춘택 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 정희순 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 송영욱 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 김영환 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 한성구 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소) ;
- 심영수 (서울대학교 의과대학 내과학교실 및 의학연구원 폐연구소)
- Park, Gun-Min (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Choi, Chang-Min (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Um, Sang-Won (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Hwang, Yong-Il (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Yim, Jae-Joon (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Lee, Jae-Ho (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Yoo, Chul-Gyu (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Lee, Choon-Taek (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Chung, Hee-Soon (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Song, Young-Wook (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Kim, Young-Whan (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Han, Sung-Koo (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine) ;
- Shim, Young-Soo (Department of Internal Medicine, Lung Institute of Medical Research Center, Seoul National University College of Medicine)
- 발행 : 2001.10.30
초록
연구배경 : 피부근염/다발성근염 환자의 폐침범에 대한 국내의 보고는 드물며, 이에 폐를 침범한 피부근염/다발성근염 환자의 임상상을 살펴보았다. 방 법 : 1989년부터 1999년까지 서울대병원을 내원한 피부근염/다발생근염 환자의 임상양상과 방사선검사를 포함한 검사소견을 후향적으로 분석하였다. 결 과 : 총 79명(피부근염/다발성근염 : 54/25명)의 환자 중 24명(33%)의 환자에서 폐침범이 있었다. 폐침범이 있는 환자군의 여성비(11:1)와 연령(
Background : Although lung involvement has been reported in 5 to 46% of dermatomyositis/polymyositis(DM/PM) patients, reports of the condition in Korea are rare. This study evaluated the clinical features of lung involvement in DM/PM patients. Methods : The medical records, laboratory results and radiologic findings of 79 DM/pM patients, who attended the Seoul National University Hospital (SNUH) between 1989 and 1999, were reviewed retrospectively. Results : A total 79 patients of whom 24 patients(33%) showed lung involvement, were enrolled in this study. More patients with lung involvement were female(F:M=11:1), and older compared with those without lung involvement. Patients with lung involvement presented with dyspnea(79%), coughing(67%), an elevated ESR, and CK/LD. Anti-Jo 1 antibody test was positive in 30%, which is significantly higher in patients with lung involvement. A simple chest X-ray of the patients with lung involvement exhibited reticular opacity(50%), reticulonodular opacity(30%), patchy opacity(29%), nodular opacity(13%) and linear opacity(4%). HRCT(n=24) showed ground glass opacity(75%), linear or septal thickening(50%), patchy consolidation(42%), honey-combing(33%) and nodular opacity(17%). The pulmonary function test showed a restrictive ventilatory pattern(77%) and a lower diffusing capacity(62%). The patients were followed up during a mean duration of