The Korean Journal of Pain
- 제14권2호
- /
- Pages.136-141
- /
- 2001
- /
- 2005-9159(pISSN)
- /
- 2093-0569(eISSN)
배양 척수감각신경세포에 대한 살리실산 나트륨의 신경독성에 관한 연구
Neurotoxicity of Sodium Salicylate on Spinal Sensory Neurons in Culture
- Lee, Kang-Chang (Department of Anesthesiology & Pain Clinic, School of Medicine Wonkwang University) ;
- Choi, Yu-Sun (Department of Anesthesiology & Pain Clinic, School of Medicine Wonkwang University) ;
- Park, Seung-Taeck (Department of Anatomy, School of Medicine, Wonkwang University)
- 발행 : 2001.12.30
초록
Background: Sodium salicylate (SS) is a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of neuralgia or pain from rheumatoid arthritis. When abused or used in excess, SS can induce cytotoxicity. The present study examined whether SS has a neurotoxic effect. Methods: Cell viability was examined by MTT [3-(4,5-dimethylthiazol-2,5-dipheny ltetrazolium bromide] assay and Sulforhodamine (SRB) assay after cultivating dorsal root ganglion (DRG) neurons derived from neonatal mouse. These cells were treated with various concentrations of SS for 24 hours. In addition, the amount of protein synthesis against SS was measured in these cultures. Results: Cell viability (20,