The Korean Journal of Pain
- Volume 14 Issue 1
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- Pages.26-31
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- 2001
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- 2005-9159(pISSN)
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- 2093-0569(eISSN)
Changes of Plasma Lidocaine Concentrations after Stellate Ganglion Block according to Volume-changes of 1% Lidocaine
성상신경절차단시 주입된 1% Lidocaine 양에 따른 혈중 Lidocaine 농도 변화
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Song, Sun-Ok
(Department of Anesthesiology, College of Medicine, Yeungnam University) ;
- Suh, Yung-Ho (Department of Anesthesiology, College of Medicine, Yeungnam University)
- Published : 2001.06.30
Abstract
Background: Sympathetic blocks with local anesthetics are used to differentiate sympathetically- maintained pain (SMP) from sympathetically-independent pain (SIP). However, systemic lidocaine is also used in the management of neuropathic pain. Therefore, there may be possibility of a false positive response in relieving their pain by systemic absorption of lidocaine following a diagnostic sympathetic block in patients with SIP. In this study, we measured the plasma lidocaine concentrations after a stellate ganglion block (SGB) using three volumes of 1% lidocaine. Methods: This prospective, crossover study was performed in 3 patients who experience sudden hearing loss and in 4 volunteers. Each person received SGB three times using three different volumes (6 ml, 12 ml and 16 ml) of 1% lidocaine at one week intervals. SGB was performed using a 23 G butterfly needle via a paratracheal approach by two persons. Two ml of venous blood was obtained from a prepared contra-lateral sided venous route at 1, 3, 5, 7, 10, 20 and 60 min after SGB. Plasma lidocaine level was analyzed by immunoassay. Results: Mean plasma lidocaine concentrations correlated well with the volumes of 1% lidocaine used in SGB; larger volumes showed higher concentrations (P < 0.01). Mean peak plasma concentrations were