The Korean Journal of Pain
- 제14권1호
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- Pages.7-11
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- 2001
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- 2005-9159(pISSN)
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- 2093-0569(eISSN)
백서의 말초신경 통증 모델에서 신경결찰 전 말초에 주입된 Bupivacaine이 기계적 통각과민의 발현에 미치는 영향
Effects of Bupivacaine Pretreatment at the Periphery on the Expression of Mechanical Hyperalgesia in a Rat Model of Peripheral Neuropathy
- 정용보 (울산대학교 의과대학 마취과학교실) ;
-
임중우
(연세대학교 의과대학 생리학교실) ;
- 정은정 (울산대학교 의과대학 마취과학교실) ;
- 이정찬 (울산대학교 의과대학 마취과학교실) ;
-
최윤
(울산대학교 의과대학 마취과학교실)
- Chung, Yong-Bo (Department of Anesthesiology, Ulsan University College of Medicine) ;
-
Leem, Joong-Woo
(Department of Physiology, Yonsei University College of Medicine) ;
- Chung, Eun-Jung (Department of Anesthesiology, Ulsan University College of Medicine) ;
- Lee, Jung-Chan (Department of Anesthesiology, Ulsan University College of Medicine) ;
-
Choi, Yoon
(Department of Anesthesiology, Ulsan University College of Medicine)
- 발행 : 2001.06.30
초록
Background: Although several mechanisms of causalgia, which results from a partial injury to the peripheral nerve trunk, have been proposed, whether or not antidromic impulses from the injured neurons contribute to the development of the mechanical hyperalgesia has not been studied. The purpose of this experiment is was to investigate the role of antidromic impulses to the peripheral sensory receptor site on the development of mechanical hyperalgesia in a rat model of peripheral neuropathy. Methods: Rats were prepared with tight ligation of by tightly ligating the left fifth and sixth lumbar spinal nerves. The effect of bupivacaine pretreatment on the development of mechanical hyperalgesia was evaluated by injecting 0.5% bupivacaine (0.3 ml) into the plantar surface of the left hind paw before the skin incision was made. For the control group, normal saline (0.3 ml) was injected instead of bupivacaine. To measure the mechanical hyperalgesia, paw withdrawal thresholds were measured using a series of von Frey hairs. Mechanical hyperalgesia was measured a the day before, and 1, 2, 3, 4, 7, and 14 days after the surgery. Results: The control group showed decreased withdrawal thresholds from the day after the surgery (the values were
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