The Korean Journal of Pain
- Volume 14 Issue 1
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- Pages.1-6
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- 2001
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- 2005-9159(pISSN)
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- 2093-0569(eISSN)
Molecular Biologic Study on the Role of Glutamate in Spinal Sensitization
척수통증과민반응에서 Glutamate의 역할에 대한 분자생물학적 연구
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Kim, Hae-Kyu
(Department of Anesthesiology, College of Medicine, Pusan National University) ;
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Jung, Jin-Sup
(Department of Physiology, College of Medicine, Pusan National University) ;
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Baik, Seong-Wan
(Department of Anesthesiology, College of Medicine, Pusan National University)
- Published : 2001.06.30
Abstract
Background: Subcutaneous injection of 5% formalin into the hind paw of the rat produces a biphasic nociceptive response. The second phase depends on changes in the dorsal horn cell function that occur shortly after an initial C-fiber discharge, spinal sensitization, or windup phenomenon. This study was performed to investigate the role of glutamate during spinal sensitization. Methods: Sprague-Dawley rats weighing 200 to 250 g were used for this study. Under light anesthesia (0.5% isoflurane) the rats were segregated in a specially designed cage and