태음조위탕(太陰調胃湯)과 마황(麻黃)이 비만(肥滿) 백서(白鼠)의 Leptin에 미치는 영향(影響)

The effect of Taeumjowetang and Herba Ephedrae on the Obese mRNA and TNF-α mRNA in obesity-induced rats

  • 신동준 (상지대학교 한의과대학 사상체질의학교실) ;
  • 김달래 (상지대학교 한의과대학 사상체질의학교실) ;
  • 김선형 (상지대학교 한의과대학 사상체질의학교실)
  • Shin, Dong-jun (Dep. of Sasang Constitutional Medicine, Graduate School of Sangji University) ;
  • Kim, Dal-rae (Dep. of Sasang Constitutional Medicine, Graduate School of Sangji University) ;
  • Kim, Sun-hyung (Dep. of Sasang Constitutional Medicine, Graduate School of Sangji University)
  • 발행 : 2000.12.31

초록

In order to investigate the effect of Taeumjowetang and Herba Ephedrae on obesity-induced rats, after Taeumjowetang and Herba Ephedrae were administered by mouth, and then body-weight, serum triglyceride, total cholesterol, Obese mRNA and TNF-${\alpha}$/ mRNA were measured. The reselts were as follows ; 1. The body-weight was decresed with the statistical significance in both the Taeumjowetang and the Herba Ephedrae group as compared with the control group. 2. The quantitation of serum triglyceride was decresed with the statistical significance in both the Taeumjowetang and the Herba Ephedrae group as compared with the control group. 3. The total cholesterol was slightly decresed in both the Taeumjowetang and the Herba Ephedrae group as compared with the control group, but there was no statistical significance. 4. The manifestation of Obese mRNA and TNF-${\alpha}$/ mRNA in epidymal, retroperitoneal, mesenteric and skeletal muscle tissues were inhibited in Taeumjowetang and Herba Ephedrae group. According to the above results, Taeumjowerang and Herba Ephedrae were recognized to be helpful for the treatment of obesity.

키워드

참고문헌

  1. 四象醫學會誌 v.5 no.1 體質別 혈청지질성분의 분석에 관한 실험적 고찰 김달래(외)
  2. 耳鍼刺戟이 肥滿人의 혈중 콜레스테롤과 트리글리세라이드의 변화에 미치는 영향 김성철
  3. 東醫壽世保元 이제마
  4. 東醫壽世保元 이제마
  5. 四象體質醫學論 윤길영
  6. 大韓東醫病理學會誌 v.10 no.1 太陰調胃湯이 白鼠의 비만증 및 유도비만세포에 미치는영향 이기주(외)
  7. 東洋醫學 v.18 no.3 肥滿症에 관한 문헌적 고찰 김동우(외 3人)
  8. 大韓內科學會誌 v.44 no.4 肥滿人에서 체중감소가 당질 및 지질 대사에 미치는 영향 허갑범(외 9인)
  9. 四象體質 유형과 체격 및 신체형태지수와의 비교연구 이문호(외)
  10. 제3의학 현곡학회 v.1 no.2 四象體質 辨證小考 고병희
  11. 中藥大辭典 김창민(외 3인)
  12. 四象醫學會誌 v.3 no.1 太陰人 남학생의 혈액변화에 대한 연구 김경요(외)
  13. 太陰調胃湯 加 麻黃이 생쥐의 비만변인에 미치는 영향 김유성
  14. Nature v.372 Zhang, Y.;Proenca, R.;Maffei, M.;Barone, M.;Leopold, L.;Friedman, J.M.
  15. Science v.269 Halaas, J.L.;Gajiwala, K.S.;Maffei, M.;Cohen, S.L.;Chait, B.T.;Rabinowitz, D.;Lallone, R.L.;Burley, S.K.;Friedman, J.M.
  16. Science v.269 Pelleymounter, M.A.;Cullen, M.J.;Baker, M.B.;Hecht, R.;Winters, D.;Boone, T.;Collins, F.
  17. Science v.269 Camfield, L.A.;Simith, F.J.;Guisez, Y.;Devos, R.;Burn, P.
  18. J. Biol. Chem. v.270 De Vos, P.;Saladin, R.;Auwerx, J.;Staels, B.
  19. FEBS Lett. v.371 Becker, D.J.;Ongemba, L.N.;Brichard, V.;Henquin, J.C.;Brichard, S.M.
  20. Proc. Natl. Acad. Sci. U.S.A. v.92 MacDougald, O.A.;Hwang, C.S.;Fan, H.;Lane, M.D.
  21. Nature v.377 Saladin, R.;DeVos, P.;Guerre-Millo, M.;Letruque, A.;Girard, J.;Staels, B.;Auwerx, J.
  22. J. Clin. Invest. v.97 Grufeld, C.;Zhao, C.;Fuller, J.;Pollock, A.;Moster, A.;Friedman, J.;Feingold, K.R.
  23. Sci. v.259 Adipose expression of tumor necrosis factor-$\alpha$: direct role in obesity-linked insulin resistance Hotamisligil, G.S.;Shargill, N.S.;Spiegelman, B.M.
  24. J. Clin. Invest. v.95 Increased adipose tissue expression of tumor necorsis factor-$\alpha$ in human obesity and insulin resistance Hotamisligil, G.S.;Arner, P.;Caro, J.F.;Atkinson, R.L.;Spiegelman, B.M.
  25. J Clin Invest v.95 The expression of tumor necrosis factor in human adipose tissue Kern, P.A.;Saghizadeh, M.;Ong, J.M.;Bosch, R.J.;Deem, R.;Simsolo, R.B.
  26. J. Exp. Med v.171 Endotoxin-responsive sequences control cachectin / tumor necrosis factor biosynthesis at the translational level Han, J.
  27. J. Rheumatol. v.23 Regulation of tumor 1 necrosis factor-$\alpha$ production: basic aspects of pharmacological modulation Huizinga, T.W.J.;Brinkman, B.M.N.;Verweij, C.L.