혜화의학회지 (Journal of Haehwa Medicine)

  • 제10권1호
  • /
  • Pages.109-114
  • /
  • 2001
  • /
  • 2586-3002(pISSN)
  • /
  • 2586-3347(eISSN)
대전대학교 한의학연구소 (Research Institute of Korean Medicine)
권호 표지

칠엽일지화(七葉一枝花)의 항종양(抗腫瘍) 효과(效果)

Study on Antitumor Activity of Paridis Rhizoma

  • 이호재 (대전대학교 한의과대학 부인과학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실) ;
  • 류동열 (대전대학교 한의과대학 부인과학교실)
  • Lee, Ho-jai (Dept. of Oriental Gynecology, College of Oriental Medicine, Daejeon University) ;
  • Kim, Dong-hee (Dept. of Oriental Pathology, College of Oriental Medicine, Daejeon University) ;
  • Yoo, Dong-Yeol (Dept. of Oriental Gynecology, College of Oriental Medicine, Daejeon University)
  • 발행 : 2001.08.26
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

To evaluate the antitumor activity of Paridis Rhizoma(PR), studies were done experimentally. The results were obtained as follows: 1. In cytotoxicity against MCF-7, SK-OV-3, HCT15, concentration inhibiting cell growth up to below 50% of control was recognized at $100-200{\mu}g/m{\ell}$ of PR and also against A549, XF498 was recognized at $50-100{\mu}g/m{\ell}$. 2. In Inhibitory effect on activity of DNA topoisomerase I, the $IC_{50}$ was shown $50-100{\mu}g/m{\ell}$ of PR. 3. The concentration inhibiting adhesion of A549 and SK-OV-3 to complex extracellular matrix up to below 50% of control was recognized at $10-100{\mu}g/m{\ell}$ of PR. 4. The T/C% was 137.9 in PR-treated group in S-180 bearing ICR mice. From above results it was concluded that PR could be usefully applied for the prevention and treatment of cancer.

키워드